Overall number of events, rates per 10 000 person years, crude and adjusted hazard ratios for coeliac cohort compared with control cohort (reference group)

Overall
First year of follow up after diagnosis
Follow up beyond year after diagnosis

Condition and cohort
No of participants^*
Hazard ratio (95% CI)
Adjusted hazard ratio (95% CI)
No of events
Rate/10 000 years
Adjusted hazard ratio (95% CI)
No of events
Rate/10 000 years
Adjusted hazard ratio (95% CI)

Any malignancy:

^*

Control
23 433
1
1
111
52.7
1
395
56.5
1

Coeliac disease
4695
1.29 (1.06 to 1.55)
1.31 (1.08 to 1.59)
44
104.2
2.07 (1.45 to 2.96)
87
62.2
1.10 (0.87 to 1.39)

Gastrointestinal cancer:

Control
23 605
1
1
14
6.6
1
64
9.0
1.00

Coeliac disease
4724
1.85 (1.22 to 2.81)
1.95 (1.27 to 3.00)
9
21.1
3.31 (1.40 to 7.83)
20
14.1
1.65 (0.99 to 2.76)

Breast cancer:

Control
23 562
1
1
24
11.3
1
87
12.3
1

Coeliac disease
4725
0.35 (0.17 to 0.72)
0.31 (0.15 to 0.63)
3
7.0
0.60 (0.18 to 2.04)
5
3.5
0.24 (0.10 to 0.60)

Lung cancer:

Control
23 616
1
1
14
6.6
1
43
6.0
1

Coeliac disease
4728
0.34 (0.13 to 0.95)
0.37 (0.13 to 1.02)
1
2.3
0.40 (0.05 to 3.09)
3
2.1
0.37 (0.11 to 1.20)

Lymphoproliferative disease:

Control
23 612
1
1
6
2.8
1
17
2.4
1

Coeliac disease
4724
4.80 (2.71 to 8.50)
4.27 (2.36 to 7.74)
11
25.8
7.32 (2.65 to 20.24)
12
8.4
3.40 (1.58 to 7.34)

Prostate cancer:

Control
23 614
1
1
4
1.9
1
25
3.5
1

Coeliac disease
4730
0.99 (0.41 to 2.38)
1.05 (0.42 to 2.57)
1
2.3
1.30 (0.14 to 12.19)
5
3.5
1.03 (0.38 to 2.76)

Mortality:

Control
23 609
1
1
184
86.7
1
697
98.0
1

Coeliac disease
4728
1.31 (1.13 to 1.51)
1.39 (1.20 to 1.61)
73
171.0
2.09 (1.59 to 2.76)
163
114.6
1.23 (1.04 to 1.47)