BMJ  2004;329 (14 August), doi:10.1136/bmj.329.7462.0-a

Perinatal death is more likely in women with previous caesareans if labour is induced with prostaglandin

Induction of labour with prostaglandin is associated with an increased risk of uterine rupture, including catastrophic rupture leading to perinatal death. In a population based study involving about 36 000 women with a previous caesarean delivery, Smith and colleagues (p 375) found that women who had not previously given birth vaginally and those whose labour was induced with prostaglandin had a higher risk of uterine rupture when attempting vaginal birth—and if uterine rupture occurred, the risk of the infant dying is lower in obstetric units with higher throughput.

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Factors predisposing to perinatal death related to uterine rupture during attempted vaginal birth after caesarean section: retrospective cohort study

Gordon C S Smith, Jill P Pell, Dharmintra Pasupathy, and Richard Dobbie
BMJ 2004 329: 375. [Abstract] [Full Text] [PDF]

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