BMJ  2004;329 (31 July), doi:10.1136/bmj.329.7460.0-b

Dronabinol has a modest analgesic effect in multiple sclerosis

A third of patients with multiple sclerosis have central pain. Cannabinoids have an analgesic effect, and a crossover trial by Svendsen and colleagues shows that they are effective in central pain also (p 253). The researchers randomised 24 patients with multiple sclerosis to dronabinol or placebo and found that patients taking the drug had modest pain relief, less intense pain, and better mental health. Patients taking dronabinol were more likely to have adverse effects, which included dizziness, than were those taking placebo.

Credit: JAMES CAVALLINI/SPL

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Does the cannabinoid dronabinol reduce central pain in multiple sclerosis? Randomised double blind placebo controlled crossover trial

Kristina B Svendsen, Troels S Jensen, and Flemming W Bach
BMJ 2004 329: 253. [Abstract] [Full Text] [PDF]