BMJ 2004;329 (10 July), doi:10.1136/bmj.329.7457.0
Are atypical neuroleptics better than the old drugs?
Newer "atypical" neuroleptic drugs may not be better than typical neuroleptics in the management of the behavioural and psychological symptoms of dementia. Lee and colleagues (p 75) reviewed five trials including 1570 patients, evaluating the four oral atypical antipsychotic therapies in patients with the disorder. They found that atypical antipsychotic drugs were superior to placebo, but not to typical antipsychotic drugs. Adverse events were common even with the new drugs and included extrapyramidal symptoms, somnolence, and abnormal gait.
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Credit: PHANIE/REX
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- Atypical antipsychotic drugs in the treatment of behavioural and psychological symptoms of dementia: systematic review
- Philip E Lee, Sudeep S Gill, Morris Freedman, Susan E Bronskill, Michael P Hillmer, and Paula A Rochon
BMJ 2004 329: 75.[Abstract] [Full Text] [PDF]
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