BMJ  2004;328:1451-1452 (19 June), doi:10.1136/bmj.328.7454.1451

Editorial

Early intervention for first episode psychosis

Needs greater involvement of primary care professionals for its success

Early intervention in psychosis is a relatively new concept in mental health. It describes the policy of the health service and its response to increasing evidence of unacceptably long delays in accessing specialist services and the benefits of earlier detection and treatment for young people who experience their first episode of psychosis (when someone displays typical symptoms, such as distorted contacts with reality, delusions, hallucinations, and thought disorder, and no organic disorder can be found to explain those symptoms). It is also a concept that requires primary and secondary care and wider involvement of the community to make a difference to the outcome.

Like most mental disorders, functional psychoses such as schizophrenia and bipolar affective disorder usually appear when people are young (80% of first episodes of psychoses occur between 16 and 30 years of age), at a critical time in their intellectual and social development and emerging personal autonomy. Worldwide, the burden of psychosis is exceeded only by quadriplegia and dementia.¹ The all cause standardised mortality ratio for schizophrenia is 298, with an unnatural cause standardised mortality ratio (that includes suicide) of 1273, 12 times higher than expected.²

Studies consistently show intervals of one to two years between the onset of psychotic symptoms and the start of treatment.³ Although still disputed, the duration of untreated psychosis is also likely to relate to outcomes in first episode psychosis, particularly functional and symptomatic outcomes at 12 months and reduction of symptoms once treatment begins.^{4 5} Long term follow up studies show that outcomes at two years strongly predict outcomes 15 years later.⁶ Birchwood argues that these observations support the concept that the early phase of psychosis constitutes a critical period for treating this illness, with major implications for secondary prevention of impairments and disabilities, and provide a further rationale for intervening intensively and early.⁷

Early intervention for psychosis has now become a political priority in the United Kingdom and early intervention services are being developed across England. The NHS Plan says that 50 early intervention teams will be established by 2004, so that all young people (between 14 and 35 years) who experience a first episode of psychosis such as schizophrenia receive the early and intensive support they need.⁸ However, new services in isolation may be insufficient to make a difference to the healthcare experience of young people with first episode psychosis and their families. To be maximally effective, early detection in primary care and facilitation of help seeking in the wider community must also be addressed.

Most general practitioners see one or two new people with a first episode of psychosis each year. Recent national guidance on schizophrenia and the mental health indicators in the new general practitioner contract may affect the roles and responsibilities of primary care by encouraging a more systematic approach to care, including the use of protocols and referral guidelines.⁹ Nevertheless some general practitioners believe that they contribute little to the care of people with serious mental illness and that the incidence of first episode psychosis is too low to warrant more active involvement.¹⁰ However, we know that general practitioners are often consulted at some point on the illness pathway on matters connected with a developing psychosis¹¹ and are the most common final referral agent. Involvement of general practitioners is also associated with reduced use of the Mental Health Act.¹² Primary care therefore has a potentially pivotal role in reducing duration of untreated psychosis and influencing the course and outcome of first episode psychosis.

Early detection is a diagnostic challenge for general practitioners when psychosis can take several months to emerge from a prodrome of non-specific psychological and social disturbances of varying intensity that can be difficult to distinguish from normal adolescent behaviour. An active watching brief typifies an approach that might regard non-attendance as a signal of deterioration rather than of resolution of symptoms. Such an approach would also involve actively seeking positive and negative psychotic symptoms and suicidal ideation. Parental fears and intuition would be particularly heeded and sensitivity given to the impact of an emerging psychosis on the family. General practitioners would have a high index of suspicion and a low threshold for urgently referring a young person with a possible first episode psychosis for specialist mental health assessment.⁹

Detection and referral are crucial but need to be underpinned by community based initiatives that promote and encourage help seeking. Such an approach makes sense for all mental illness, not just psychosis where the stakes are arguably the highest. Primary care trusts have a role in promoting mental health within the communities they represent and helping to reduce the stigma of mental illness. Early results from the "Treatment and Intervention Psychosis" project in Norway show that a programme of extensive public education and specific education for teachers, youth workers, and general practitioners about first episode psychosis can reduce the duration of untreated psychosis.

The real challenge for primary care therefore goes beyond improving the competence and knowledge of individual general practitioners or raising awareness of the new early intervention services. The concept of early intervention puts the onus on primary care and other community services to make themselves accessible, non-stigmatising, and relevant to young people, whether dealing with a mild and self limiting depression or a major psychosis. Young people with emerging psychoses and their families also need to feel confident that primary care services will integrate with the new early intervention services to ensure they receive the highly specialised interventions they require both at the onset of the illness and in the longer term in a timely fashion. If we achieve that then early intervention really will have become everybody's business.

National Institute of Mental Health for England, West Midlands, West Midlands Mental Health Development Centre, Redditch B97 4DE (david.shiers{at}doctors.org.uk)

Department of Primary Care and General Practice, Medical School, University of Birmingham, Birmingham B15 2TT (H.E.Lester{at}bham.ac.uk)

---

Competing interests: None declared.

References

1. World Health Organization. Mental health: new understanding, new hope. Geneva: WHO, 2001.
2. Brown S, Inskip H, Barraclough B. Causes of excess mortality of schizophrenia. Br J Psychiatry 2000;177: 212-7.[Abstract/Free Full Text]
3. McGlashan TH. Duration of untreated psychosis in first episode schizophrenia: Marker or determinant of course. Biological Psychiatry 1999;46: 899-907.[CrossRef][ISI][Medline]
4. Norman R, Malla A. Duration of untreated psychosis: A critical examination of the concept and its importance. Psychol Med 2001;31: 381-400.[ISI][Medline]
5. Drake R, Haley C, Akhtar S, Lewis S. Causes and consequences of duration of untreated psychosis in schizophrenia. Br J Psychiatry 2000;177: 511-5.[Abstract/Free Full Text]
6. Harrison G, Hopper K, Craig T, Laska E, Siegel C, Wanderling J, et al. Recovery from psychotic illness: A 15 and 25 year international follow up study. Br J Psychiatry 2001;178: 506-17.[Abstract/Free Full Text]
7. Birchwood M, Todd P, Jackson C. Early intervention in psychosis, the critical period hypothesis. Br J Psychiatry 1998;172(suppl 33): S53-9.
8. Department of Health. The national plan for the NHS. London: Department of Health, 2000: 119.
9. National Collaborating Centre for Mental Health. Schizophrenia: full national clinical guidelines on core interventions in primary and secondary care. Trowbridge: Royal College of Psychiatrists, British Psychological Society, 2003.
10. Bindman J, Johnson S, Wright S, Szmukler G, Bebbington P, Kuipers E, et al. Integration between primary and secondary services in the care of the severely mentally ill: patients' and general practitioners' views. Br J Psychiatry 1997;171: 169-74.[Abstract/Free Full Text]
11. Cole E, Levy G, King M, Johnson-Sabrine E, Hoar A. Pathways to care for patients with a first episode of psychosis. A comparison of ethnic groups. Br J Psychiatry 1995;167: 770-6.[Abstract/Free Full Text]
12. Burnett R, Mallett R, Bhugra G, Hutchinson G, Der G, Leff J. The first contact of patients with schizophrenia with psychiatric services: social factors and pathways to care in multi-ethnic population. Psychol Med 1999;29: 475-83.[CrossRef][ISI][Medline]

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