BMJ  2004;328 (12 June), doi:10.1136/bmj.328.7453.0-d

Does eradicating H pylori improve gastric symptoms?

Eradication of Helicobacter pylori does not increase or reduce symptoms of gastro-oesophageal reflux. Harvey and colleagues (p 1417) randomised 1558 patients with H pylori infection to receive active treatment or placebo and found that, two years after treatment, eradication had no effect on the overall prevalence of heartburn or reflux, nor on pre-existing gastric symptoms. In participants who had isolated reflux, treatment prevented the development of heartburn.


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Relevant Article

Randomised controlled trial of effects of Helicobacter pylori infection and its eradication on heartburn and gastro-oesophageal reflux: Bristol helicobacter project
Richard F Harvey, J Athene Lane, Liam J Murray, Ian M Harvey, Jenny L Donovan, and Prakash Nair
BMJ 2004 328: 1417. [Abstract] [Full Text] [PDF]

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