BMJ  2004;328 (21 February), doi:10.1136/bmj.328.7437.0-c

Aspirin induced asthma is more common than previously suggested

The prevalence of aspirin induced asthma is higher than previously suggested. In a systematic review, Jenkins and colleagues (p 434) found that the prevalence of aspirin induced asthma was higher when determined by oral provocation testing than verbal history (21% v 3% in adults, 5% v 2% in children). Most patients were sensitive to NSAIDs, but sensitivity to paracetamol (7% of patients) was more likely in patients highly sensitive to aspirin. Since aspirin and other anti-inflammatory drugs are often self prescribed, patients with asthma should be alerted to the possibility of cross reaction. Simple, standardised warnings on packs of aspirin and NSAIDs may be indicated.

Credit: BAYER AG

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Systematic review of prevalence of aspirin induced asthma and its implications for clinical practice

Christine Jenkins, John Costello, and Linda Hodge
BMJ 2004 328: 434. [Abstract] [Full Text] [PDF]