BMJ 2004;328 (21 February), doi:10.1136/bmj.328.7437.0-b
Evidence of success of blinding in clinical trials is scant
The success of blinding in placebo controlled trials is not well reported, and when it is reported it is often poor. Fergusson and colleagues (p 432) evaluated 191 randomised placebo controlled double blind trials published between 1998 and 2001 in nine general medicine or psychiatry journals. They found that only 15 trials (8%) provided information on the success of blinding, and that it was successful in only five trials. The validity of double blinding was reported in only four of the 191 articles.
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- Turning a blind eye: the success of blinding reported in a random sample of randomised, placebo controlled trials
- Dean Fergusson, Kathleen Cranley Glass, Duff Waring, and Stan Shapiro
BMJ 2004 328: 432.[Abstract] [Full Text] [PDF]
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