BMJ  2004;328:385-386 (14 February), doi:10.1136/bmj.328.7436.385

Paper

Variations and increase in use of statins across Europe: data from administrative databases

¹ Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3GF, ² IRPPS/CNR, via Nizza 128, I-00198 Rome, Italy, ³ Pharmacologisckes Institut, Ruprecht-Karls-Universität Im Neuenheimer Feld 366, 69120-Heidelberg, Germany, ⁴ Unité de Pharmacoépidémiologie, University of Lyon, France

Introduction

Coronary heart disease remains a major cause of death in most European countries.¹ Statins lower blood cholesterol concentration and reduce the relative risk of coronary events by about 30% in both primary and secondary prevention.² Statins are widely and increasingly used in most European countries, although data on the extent of this are not generally available.

Methods and results

As part of a wider study on drug use,³ we collected data on statin use by total defined daily doses and then calculated doses per 1000 of the population covered (by the relevant data source) in 13 of the 15 European Union countries and in Norway for the year 2000. The data sources were the major publicly supported sources, mostly governmental or major insurance or sickness funds (see appendix 2 on bmj.com for details). These systems cover all or only part of a population, and only the publicly funded use (except Sweden, which includes both public and the small privately reimbursed use) in the community (except Norway, which includes use in small hospitals). For instance, the Irish data refer only to the population covered by the General Medical Services Scheme (the poorest third of the population, who are probably also at highest cardiovascular risk); for Germany, the Netherlands, France, and Portugal, the data refer to the population covered by Social Insurances (75-90% of the whole population, according to the country); "UK" data refer to England only (83% of UK population). For Austria and Belgium, only aggregated data on total use and expenditure were available.

Use of statins across Europe was extensive but variable (table). The widest use was in Norway, with over five times the per capita use than in Italy, which had the lowest use. The market leading drug varied between countries, but the most common were simvastatin and atorvastatin. Statin use rose rapidly in all the countries studied: the European average, weighted by population of each country reporting in that year, rose from 11.12 defined daily doses/1000 in 1997 to 41.80/1000 in 2002, an average 31% increase a year.

View this table: [in this window] [in a new window]   Use of different statins in European countries in 2000

 

Comment

Our analysis shows enormous variation in statin use across Europe and a rapid increase in use. Variations in morbidity may explain some of the differences in use (such as between Italy and Britain) but not all (as between Norway and Denmark). We must consider other explanations, and these may lie in factors unique to each country: for example, differences between Norway and Denmark may reflect the involvement of Norwegian doctors in seminal trials, while in Denmark these drugs were only reimbursed from 1998 onwards and their use has lagged behind other countries. Low use in Italy may reflect low coronary morbidity or poor adherence of Italian patients to statins, worse than elsewhere in Europe.⁴ Other differences may lie in national guidance and policies. These national figures also hide wide variations within countries.⁵

The rapid increase in use may be due to a growing awareness of the effectiveness of these drugs as their evidence base has expanded² or to government policies that have stressed more aggressive management of risk factors for ischaemic heart disease (such as in Britain). Some of the effect may be due to successful marketing, particularly since the market leaders in many countries were drugs with no evidence of benefits in mortality at the time. This may also explain in part why the heaviest use was in France, which had relatively low cardiovascular mortality even before statins were available. Political, cultural, and social issues determine such use as well as medical indications. In view of the public health implications, these merit more specific study in each country.

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Potential influences on results and supplementary data are on bmj.com

Contributors: All members of EuroMedStat contributed to data collection and analysis. All named authors helped to draft this article. PF-G is the project coordinator. TW is guarantor for the article.

Funding: This work was funded by the European Commission, which had no role in the design, data collection, data analysis, interpretation, or writing of this report.

Competing interests: EvG has received unrestricted research funds from a company that manufactures a statin.

References

1. World Health Organization. European health for all database. Updated January 2003 http://www.euro.who.int/hfadb (accessed 29 Apr 2003).
2. Sudlow C, Lonn E, Pignone M, Ness A, Rihal C. Secondary prevention of ischaemic cardiac events. In: Clinical evidence. Issue 9. London: BMJ Publishing, 2003: 166-205.
3. The Euro-Med-Stat Group. Euro-Med-Stat: monitoring expenditure and utilisation of medicinal products in the European Union countries. A public health approach. Eur J Public Health (in press).
4. Larsen J, Vaccheri A, Andersen M, Montanaro N, Bergman U. Lack of adherence to lipid-lowering drug treatment. A comparison of utilization patterns in defined populations in Funen, Denmark and Bologna, Italy. Br J Clin Pharmacol 2000;49: 463-71.[CrossRef][Web of Science][Medline]
5. Majeed A, Moser K, Maxwell R. Age, sex and practice variations in the use of statins in general practice in England and Wales. J Public Health Med 2000;22: 275-9.[Abstract/Free Full Text]

(Accepted 26 November 2003)

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