BMJ  2004;328 (31 January), doi:10.1136/bmj.328.7434.0

Triple therapy is the best treatment for some HIV patients

Triple regimens with protease inhibitors may be superior to regimens based on non-nucleoside reverse transcriptase inhibitors and to two nucleoside reverse transcriptase inhibitor regimens in adults with advanced HIV infection. In a systematic review and indirect meta-analysis, Yazdanpanah and colleagues (p 249) analysed data on 6785 patients included in 14 trials, comparing triple and dual therapy for HIV infection. They found that, in patients with advanced disease who had been exposed to nucleoside reverse transcriptase inhibitors, protease inhibitor based triple regimens are superior to other treatment for preventing progression to AIDS or death.

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Relevant Article

Clinical efficacy of antiretroviral combination therapy based on protease inhibitors or non-nucleoside analogue reverse transcriptase inhibitors: indirect comparison of controlled trials

Yazdan Yazdanpanah, Daouda Sissoko, Matthias Egger, Yves Mouton, Marcel Zwahlen, and Geneviève Chêne
BMJ 2004 328: 249. [Abstract] [Full Text] [PDF]

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