Contribution of autopsy in 132 cases of termination of pregnancy due to structural anomalies detected at scan with no evidence for abnormal karyotype and autopsy performed

Category Contribution of autopsy No (%) of cases Example 1 Prenatal diagnosis confirmed; scan and autopsy findings identical 72 (55%) Scan=isolated anencephaly; autopsy =isolated anencephaly 2 Prenatal diagnosis confirmed; autopsy added some information which did not change recurrence risk 23 (17%) Scan=anencephaly; autopsy =anencephaly + unilateral renal agenesis 3a Autopsy added information that reduced estimate of recurrence risk 17 (13%) Scan=anencephaly; autopsy =amniotic band 3b Autopsy added information that increased estimate of recurrence risk 18 (14%) Scan=cystic kidneys; autopsy =infantile polycystic kidney disease 4 Other (see text) 2 (2%)