BMJ  2003;327 (6 December), doi:10.1136/bmj.327.7427.0-b

Medium dose aspirin may improve graft patency

Taking 300 mg of aspirin may prevent occlusion of bypasses more effectively than 150 mg or less. Lim and colleagues (p 1309) conducted an indirect comparison meta-analysis on 3281 patients taking low (< 150 mg) or medium (300-325 mg) doses of aspirin in the year after surgery. All patients were studied by coronary angiography. Although the difference was not statistically significant, there was a trend towards better graft patency (risk ratio 0.74) and reduced coronary events (risk ratio 0.81) with medium dosage, and this may be the optimum dose in the first year.

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Indirect comparison meta-analysis of aspirin therapy after coronary surgery

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