BMJ  2003;327 (2 August), doi:10.1136/bmj.327.7409.0-a

Enzyme potentiated desensitisation fails to prevent hay fever

Allergy injections don't work against severe summer hay fever. In a randomised controlled trial Radcliffe and colleagues (p 251) tested the effectiveness of enzyme potentiated desensitisation in 183 patients with seasonal allergic rhinitis who had not responded to standard treatment. They found no differences between the intervention and placebo groups in the number of problem free days, quality of life, severity of symptoms, and adverse reactions. Six previous smaller studies had found the enzyme ({beta} glucuronidase) to be effective.

Credit: TERRY TUTTLE/BLM


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Relevant Article

Enzyme potentiated desensitisation in treatment of seasonal allergic rhinitis: double blind randomised controlled study
Michael J Radcliffe, George T Lewith, Richard G Turner, Philip Prescott, Martin K Church, and Stephen T Holgate
BMJ 2003 327: 251-254. [Abstract] [Full Text] [PDF]




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