Variable and group Baseline Difference (95% CI) 6 weeks Difference (95% CI) 12 weeks Difference (95% CI) 1 year Difference (95% CI) Success rate: Therapy — — — 43/127 (34) 3.6 (-8.0 to 15.1) — Placebo — — 39/129 (30) — Roles and Maudsley* score 1 or 2: Therapy 0/135 (0) Inclusion criterion 28/129 (22) 3.3 (-13.7 to 7.1) 58/127 (46) 5.4 (-7.0 to 17.5) 91/113 (81) 4.9 (-6.0 to 16.0) Placebo 0/136 (0) 33/132 (25) 52/129 (40) 87/115 (76)

^* Pain score according to Roles and Maudsley.¹⁸

Only patients with score of 3 or 4 included, therefore no patient had 1 or 2 at baseline.