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BMJ 2003;327 (5 July), doi:10.1136/bmj.327.7405.0-a
The risk of hepatotoxicity associated with non-steroidal anti-inflammatory drugs, including nimesulide, is small. A five year retrospective cohort study by Traversa and colleagues looked at almost 2 million prescriptions in the Umbria region of Italy (p 18). It found no significant increase in risk when the incidence of hepatopathy among users of nimesulide was compared with other non-steroidal anti-inflammatory drugs. Nimesulide has been withdrawn from use in Finland and Spain because of reported increases in liver injury.
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