References

Table A

 

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Web table A Average changes (95% confidence intervals) in persons taking thiazides, according to dose, in serum concentrations of total cholesterol and its low (LDL), high (HDL) and very low (VLDL) density lipoprotein subfractions, potassium, glucose, uric acid, adjusted for changes in the placebo groups, in randomised trials of thiazides

Web table A Average changes (95% confidence intervals) in persons taking thiazides, according to dose, in serum concentrations of total cholesterol and its low (LDL), high (HDL) and very low (VLDL) density lipoprotein subfractions, potassium, glucose, uric acid, adjusted for changes in the placebo groups, in randomised trials of thiazides

Dose of thiazide:

Half-standard dose

Standard dose

Twice-standard dose

No of trials*

Average change (mmol/l)

change as % of mean

Average change (mmol/l)

change as % of mean

Average change (mmol/l)

change as % of mean

Cholesterol:

13

total

0.06 (-0.04 to 0.17)†

1%

0.18 (0.10 to 0.27)

3%

0.30 (0.14 to 0.47)

5%

LDL

-0.09 (-0.28 to 0.11)†

-2%

-0.04 (-0.02 to 0.13)†

-1%

0.01 (-0.23 to 0.26)†

1%

HDL

-0.03 (-0.08 to 0.03)†

-2%

-0.004 (-0.01 to 0.02)†

0%

0.03 (-0.01 to 0.08)†

3%

VLDL

0.07 (-0.09 to 0.23)†

12%

0.13 (0.03 to 0.23)

22%

0.19 (0.09 to 0.29)

32%

Potassium

27

-0.21 (-0.28 to -0.14)

-6%

-0.38 (-0.44 to -0.33)

-9%

-0.55 (-0.64 to -0.46)

-13%

Glucose

15

0.06 (0.00 to 0.12)

1%

0.19 (0.10 to 0.27)

3%

0.31 (0.18 to 0.45)

5%

Uric acid

20

0.032 (0.027 to 0.037)

9%

0.048 (0.043 to 0.053)

15%

0.064 (0.054 to 0.074)

21%

† Not statistically significant; however upper confidence interval is informative

* Reference numbers:

Cholesterol fractions: w2,w22,w28,w31,w33,w36,w44,w47-50,w56,w57

Potassium: w4,w25-41,w47-52,w56,w61,w63.

Glucose: w2,w28,w31-38,w47-50,w56

Uric acid: w9,w29-40,w47-51,w56,w63

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