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Anticholinergic agents benefit some patients with overactive bladders,
but the effects may be of limited clinical importance. Herbison and
colleagues (p 841) conducted a systematic review of 32 randomised
controlled trials that compared anticholinergics with placebo in
treating overactive bladder syndrome. The study found that patients
taking anticholinergics had one less incontinent episode and one less
need to void every two days than patients taking placebo. They were
more likely to have dry mouth, the most common side effect of treatment.