Anticholinergics have unclear benefits in overactive bladder syndrome

Anticholinergic agents benefit some patients with overactive bladders, but the effects may be of limited clinical importance. Herbison and colleagues (p 841) conducted a systematic review of 32 randomised controlled trials that compared anticholinergics with placebo in treating overactive bladder syndrome. The study found that patients taking anticholinergics had one less incontinent episode and one less need to void every two days than patients taking placebo. They were more likely to have dry mouth, the most common side effect of treatment.


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Relevant Article

Effectiveness of anticholinergic drugs compared with placebo in the treatment of overactive bladder: systematic review
Peter Herbison, Jean Hay-Smith, Gaye Ellis, and Kate Moore
BMJ 2003 326: 841-844. [Abstract] [Full Text] [PDF]




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