Increase in blood glucose predicts myocardial infarction

An increase in blood glucose during antihypertensive treatment is an independent risk factor for myocardial infarction. Dunder and colleagues (p 681) studied a cohort of 1860 Swedish men who had participated in a baseline investigation when aged 50 and who were re-examined at age 60. A significant interaction existed between proinsulin concentration at baseline and antihypertensive treatment on increase in blood glucose, suggesting that the metabolic impact of antihypertensives increases the risk of myocardial infarction in an insulin resistant state.

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Relevant Article

Increase in blood glucose concentration during antihypertensive treatment as a predictor of myocardial infarction: population based cohort study

Kristina Dunder, Lars Lind, Björn Zethelius, Lars Berglund, and Hans Lithell
BMJ 2003 326: 681. [Abstract] [Full Text] [PDF]