Women with diabetes should avoid HRT

Women with diabetes who use hormone replacement therapy (HRT) are at greater risk of ischaemic heart disease than are non-users with diabetes. Using information from registries and self reports, Løkkegaard and colleagues (p 426) prospectively studied a large cohort of Danish nurses and found that current users with diabetes had an increased risk of death, ischaemic heart disease, and heart attack. That HRT conferred no protective effect on ischaemic heart disease is contrary to the findings of previous observational studies.

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Relevant Article

Relation between hormone replacement therapy and ischaemic heart disease in women: prospective observational study

E Løkkegaard, A T Pedersen, B L Heitmann, Z Jovanovic, N Keiding, Y A Hundrup, E B Obel, and B Ottesen
BMJ 2003 326: 426. [Abstract] [Full Text] [PDF]