Folate and vitamin B-12 do not reduce cardiovascular mortality

Lower concentrations of folate and vitamin B-12 do not increase the risk of death from cardiovascular disease, finds a community cohort study. Hung and colleagues (p 131) monitored survival in almost 3000 Australian women and men for 29 years. Moderately raised homocysteine, which is usually due to inadequate folate and B vitamins, is thought to be an independent risk factor for cardiovascular disease, but this study found no evidence of an independent association between folate or vitamin B-12 concentrations and death from cardiovascular or coronary heart disease. Routine vitamin supplementation in the general population to prevent cardiovascular disease should await evidence from clinical trials.

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Relevant Article

Folate and vitamin B-12 and risk of fatal cardiovascular disease: cohort study from Busselton, Western Australia

Joseph Hung, John P Beilby, Matthew W Knuiman, and Mark Divitini
BMJ 2003 326: 131. [Abstract] [Full Text] [PDF]