Tricyclics work at low dosages
Prescribing low dosage tricyclic drugs for depression is justified,
despite criticisms of such practice. In a systematic review of 41 studies Furukawa and colleagues (p 991) found that low dosage tricyclics (between 75 and 100 mg/day, and possibly below this range)
were more effective than placebo. The number needed to treat to
bring about a response in depression was between 4 and 6 at 1-6 months
of treatment.
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- Meta-analysis of effects and side effects of low dosage tricyclic antidepressants in depression: systematic review
- Toshi A Furukawa, Hugh McGuire, and Corrado Barbui
BMJ 2002 325: 991.[Abstract] [Full Text] [PDF]
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