Link between polymorphism and coronary restenosis may be due to bias

Studies have suggested that genetic susceptibility is an important determinant of coronary restenosis after percutaneous coronary intervention. In a meta-analysis of 16 published studies of the angiotensin converting enzyme insertion or deletion polymorphism and restenosis, however, Bonnici and others (p 517) showed weaker associations between the DD genotype and restenosis in larger and more rigorous studies than in other studies. They conclude that biases in genetic epidemiological studies of customary size and quality can produce artefactual associations at least as large as those that might be realistically expected for common polymorphisms in complex diseases.

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Relevant Article

Angiotensin converting enzyme insertion or deletion polymorphism and coronary restenosis: meta-analysis of 16 studies

François Bonnici, Bernard Keavney, Rory Collins, and John Danesh
BMJ 2002 325: 517-520. [Abstract] [Full Text] [PDF]