NT-proBNP assay can effectively rule out heart failure
The potential for diagnosing heart failure by serological testing for
natriuretic peptides is reinforced by a study by Hobbs and colleagues
(p 1498). A new assay for N-terminal pro-brain natriuretic peptide
(NT-proBNP) exhibited a very high negative predictive value for heart
failure in a large population of community based patients. This means
that a diagnosis of heart failure could effectively be ruled out on the
basis of normal concentrations of NT-proBNP. Patients with raised
concentrations would still need confirmation of diagnosis by echocardiography.
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- Reliability of N-terminal pro-brain natriuretic peptide assay in diagnosis of heart failure: cohort study in representative and high risk community populations
- F D R Hobbs, R C Davis, A K Roalfe, R Hare, M K Davies, and J E Kenkre
BMJ 2002 324: 1498.[Abstract] [Full Text] [PDF]
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