Table 3.  Rate ratios (95% confidence intervals) for hospital admissions over 21 years from first screening by level of perceived stress at first screening


Perceived stress No of admissions Adjusted for age Adjusted for age and social class Adjusted for age, social class, and risk factors*

All cause, general hospital:
  High 1913 1.10 (0.98 to 1.23) 1.15 (1.03 to 1.29) 1.13 (1.01 to 1.27)
  Medium 6749 0.97 (0.89 to 1.05) 1.04 (0.96 to 1.13) 1.03 (0.95 to 1.11)
  Low 4240 1.00 1.00 1.00
  P for trend 0.32 0.021 0.048
Cardiovascular disease:
  High  524 1.14 (0.94 to 1.37) 1.22 (1.01 to 1.47) 1.20 (1.00 to 1.45)
  Medium 1740 0.96 (0.84 to 1.09) 1.06 (0.93 to 1.21) 1.03 (0.91 to 1.18)
  Low 1105 1.00 1.00 1.00
  P for trend 0.38 0.049 0.081
Coronary heart disease:
  High  215 0.94 (0.72 to 1.24) 1.00 (0.76 to 1.33) 1.00 (0.76 to 1.32)
  Medium  845 0.94 (0.78 to 1.14) 1.02 (0.84 to 1.23) 0.96 (0.79 to 1.16)
  Low  544 1.00 1.00 1.00
  P for trend 0.57 0.93 0.90
Acute myocardial infarction:
  High   91 0.79 (0.59 to 1.06) 0.82 (0.61 to 1.10) 0.86 (0.65 to 1.15)
  Medium  399 0.89 (0.74 to 1.08) 0.93 (0.77 to 1.14) 0.93 (0.76 to 1.13)
  Low  272 1.00 1.00 1.00
  P for trend 0.10 0.20 0.29
Angina:
  High   45 1.17 (0.69 to 2.00) 1.35 (0.79 to 2.31) 1.32 (0.78 to 2.26)
  Medium  135 0.87 (0.60 to 1.27) 1.01 (0.69 to 1.49) 1.01 (0.68 to 1.50)
  Low   94 1.00 1.00 1.00
  P for trend 0.80 0.35 0.38
Hypertension, varicose veins, and ill defined conditionsdagger :
  High  107 1.72 (1.25 to 2.37) 1.83 (1.32 to 2.53) 1.91 (1.38 to 2.64)
  Medium  322 1.26 (1.00 to 1.61) 1.36 (1.06 to 1.73) 1.39 (1.09 to 1.77)
  Low  153 1.00 1.00 1.00
  P for trend 0.001 <0.001 <0.001
Other cardiovascular diseaseDagger :
  High  253 1.08 (0.84 to 1.40) 1.14 (0.88 to 1.48) 1.14 (0.88 to 1.48)
  Medium  809 0.88 (0.74 to 1.06) 0.98 (0.81 to 1.17) 0.99 (0.82 to 1.19)
  Low  550 1.00 1.00 1.00
  P for trend 0.96 0.45 0.43
Psychiatric disorders:
  High  103 2.20 (1.33 to 3.65) 2.34 (1.41 to 3.91) §
  Medium  212 1.10 (0.76 to 1.60) 1.18 (0.80 to 1.73) §
  Low  114 1.00 1.00 §
  P for trend 0.004 0.002

Participants in each stress category: high stress n=743, medium stress n=3037, and low stress n=1826.
* Risk factors: smoking (cigarettes per day, past, current, never smokers), alcohol consumption (0, >0-15, >= 15 units weekly), weekly hours of exercise, cholesterol concentration (mmol/l), diastolic blood pressure (mm Hg), body mass index (kg/m2), percentage of forced expiratory volume in one second. Participants with missing values excluded.
dagger Includes ICD9 codes 401 (hypertension) 189 admissions; 429 (ill defined heart disease) 12 admissions; 454 (lower limb varicose veins) 156 admissions; 455 (haemorrhoids) 147 admissions; 456 (other varicose veins) 35 admissions; 457 (lympho-oedema) 2 admissions; 458 (hypotension) 14 admissions; 459 (other circulatory disorders) 27 admissions.
Dagger Includes ICD9 codes 393-398 (chronic rheumatic heart disease) 43 admissions; 402-405 (hypertensive disease other than essential hypertension) 15 admissions; 415-417 (diseases of the pulmonary circulation) 67 admissions; 420-425 (diseases of the pericardium, endocardium, and myocardium) 73 admissions; 426-428 (conduction disorders, dysrhythmias, and heart failure) 469 admissions; 430-438 (cerebrovascular disease) 401 admissions; 440-448 (diseases of arteries, arterioles, and capillaries) 449 admissions; 451 (phlebitis) 60 admissions; 453 (venous embolism and thrombosis) 35 admissions.
§ Not reported as cardiovascular risk factors were not expected to confound a relation with psychiatric disease.




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