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New evidence supports the use of up to three antiretroviral drugs to
treat people with HIV. Jordan and colleagues (p 757) report that
combinations of up to three drugs are consistently and significantly
more effective, but there is inadequate evidence on the effectiveness
of four or more drugs. Further work is needed on the effectiveness of
quadruple therapies and the relative effectiveness of specific
combinations of drugs.

(Credit: SUSAN STERNER/SPL)