Can animal experiments inform human health care?

Animal experiments can inform human health care only if their results are valid and can be generalised. A systematic review of animal experiments on fluid resuscitation found that most studies were underpowered and provided little information on potential bias. Roberts and colleagues (p 474) suggest that systematic reviews across species would help determine whether the results could be generalised to humans.
 
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Relevant Article

Does animal experimentation inform human healthcare? Observations from a systematic review of international animal experiments on fluid resuscitation
Ian Roberts, Irene Kwan, Phillip Evans, and Steven Haig
BMJ 2002 324: 474-476. [Extract] [Full Text] [PDF]




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