lactam use increases chance of children carrying penicillin
resistant pneumococci
The likelihood of a child carrying pneumococci resistant to penicillin
increases with longer previous use of 
lactam. Nasrin and
colleagues (p 28) found that the presence of lactam resistant pneumococci was significantly associated with length of lactam use in the previous two months and that the probability of carriage of
the resistant organisms increased by 4% for each additional day of
lactam use in the previous six months.
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Effect of lactam antibiotic use in children on pneumococcal resistance to penicillin: prospective cohort study
- Dilruba Nasrin, Peter J Collignon, Leslee Roberts, Eileen J Wilson, Louis S Pilotto, and Robert M Douglas
BMJ 2002 324: 28.[Abstract] [Full Text] [PDF]
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