Thyroxine does not benefit euthyroid people with symptoms of hypothyroidism

Thyroxine is no more effective than placebo in improving cognitive function and psychological wellbeing in patients with symptoms of hypothyroidism but with thyroid function tests within the normal range. In addition, thyroxine does not improve cognitive function and psychological wellbeing in healthy adults. Pollock and colleagues (p 891) conducted a randomised, double blind, placebo crossover trial on 22 patients with symptoms of hypothyroidism, but biochemically euthyroid, and 19 healthy controls. They also found that there was no significant changes in clinical measurements such as blood pressure, pulse rate, or weight during the study.

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Relevant Article

Thyroxine treatment in patients with symptoms of hypothyroidism but thyroid function tests within the reference range: randomised double blind placebo controlled crossover trial

M Anne Pollock, Alison Sturrock, Karen Marshall, Kate M Davidson, Christopher J G Kelly, Alex D McMahon, and E Hamish McLaren
BMJ 2001 323: 891-895. [Abstract] [Full Text] [PDF]

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Thyroxine DOES benefit euthyroid people with symptoms of hypothyroidism

Clive R Arnold
bmj.com, 4 Apr 2007 [Full text]