Risk of upper gastrointestinal bleeding increases with inhibition of serotonin reuptake
Antidepressants with high inhibition of serotonin reuptake increase the
risk of upper gastrointestinal bleeding particularly in patients aged
over 80 and those with previous gastrointestinal bleeds. In their
retrospective cohort study of 317 824 elderly patients in Canada,
Walraven and colleagues (p 655) found that, after adjustment for age
and previous gastrointestinal bleeding, the risk of bleeding increased
by 10.7% and 9.8% respectively with increasing inhibition of
serotonin reuptake.
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- Inhibition of serotonin reuptake by antidepressants and upper gastrointestinal bleeding in elderly patients: retrospective cohort study
- C van Walraven, M M Mamdani, P S Wells, and J I Williams
BMJ 2001 323: 655.[Abstract] [Full Text] [PDF]
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