BMJ 2001;323:257-260 ( 4 August )

Papers

Cohort study of depressed mood during pregnancy and after childbirth

Jonathan Evans, consultant senior lecturer a, Jon Heron, research assistant b, Helen Francomb, midwife c, Sarah Oke, consultant psychiatrist d, Jean Golding, professor of paediatric epidemiology b,  on behalf of the Avon Longitudinal Study of Parents and Children Study Team.

a Division of Psychiatry, University of Bristol, Bristol BS2 8DZ, b Unit of Paediatric and Perinatal Epidemiology, Division of Child Health, University of Bristol, Bristol BS8 1TQ, c Department of Women's Health and Care of the Newborn, North Bristol NHS Trust, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, d Mother and Baby Unit, Barrow Hospital, Barrow Gurney, Bristol BS48 3SG

Correspondence to: J Evans j.evans{at}bristol.ac.uk


    Abstract
Top
Abstract
Introduction
Participants and methods
Results
Discussion
References

Objective: To follow mothers' mood through pregnancy and after childbirth and compare reported symptoms of depression at each stage.
Design: Longitudinal cohort study.
Setting: Avon.
Participants: Pregnant women resident within Avon with an expected date of delivery between 1 April 1991 and 31 December 1992.
Main outcome measures: Symptom scores from the Edinburgh postnatal depression scale at 18 and 32 weeks of pregnancy and 8 weeks and 8 months postpartum. Proportion of women above a threshold indicating probable depressive disorder.
Results: Depression scores were higher at 32 weeks of pregnancy than 8 weeks postpartum (difference in means 0.88, 95% confidence interval 0.79 to 0.97). There was no difference in the distribution of total scores or scores for individual items at the four time points. 1222 (13.5%) women scored above threshold for probable depression at 32 weeks of pregnancy, 821 (9.1%) at 8 weeks postpartum, and 147 (1.6%) throughout. More mothers moved above the threshold for depression between 18 weeks and 32 weeks of pregnancy than between 32 weeks of pregnancy and 8 weeks postpartum.
Conclusions: Symptoms of depression are not more common or severe after childbirth than during pregnancy. Research and clinical efforts need to be moved towards understanding, recognising, and treating antenatal depression.


    Introduction
Top
Abstract
Introduction
Participants and methods
Results
Discussion
References

Women are more vulnerable to psychiatric illness during the postnatal period. The rate of psychiatric admission is increased postnatally, mostly because of the raised risk of psychosis in the first month after childbirth.1 In 1968, Pitt described a syndrome of "atypical depression following childbirth,"2 although there is now no evidence that there is a categorical difference between depression after childbirth and depression at other times. The prevalence of non-psychotic depressive illness in the postnatal period is similar to that in the general population. 3 4

Nevertheless, postnatal depression has become a focus of concern. General practitioners, health visitors, and others are exhorted to recognise and treat this condition. The consequences of postnatal depression to the child, mother, and family may include neglect of the child, family breakdown, self harm, and suicide. However, the more common consequences include emotional and behavioural problems, and cognitive delay in the children of depressed mothers. 5 6

In contrast, depression during pregnancy has been relatively neglected. Indeed, pregnancy was thought to protect women against depression. Studies of antenatal psychopathology have mostly examined antenatal mood as a predictor of postnatal depression.7-10 Watson et al found that in 23% of those who had postnatal depression this had started during pregnancy.11 Depressed mood during pregnancy has also been associated with poor attendance at antenatal clinics, substance misuse, low birth weight, and preterm delivery. 12 13 Psychopathological symptoms during pregnancy have physiological consequences for the fetus, which may explain some of these effects.14

We studied mood through pregnancy and after childbirth using prospectively gathered data from a cohort of 14 000 women. We compared depressive symptom score, the pattern of reported symptoms, and the proportion of mothers above a threshold indicating probable depressive disorder at each stage.


    Participants and methods
Top
Abstract
Introduction
Participants and methods
Results
Discussion
References

The Avon longitudinal study of parents and children enrolled women resident in Avon who were in the early stages of pregnancy with an expected date of delivery between 1 April 1991 and 31 December 1992. We recruited 14 541 women, of whom 13 799 had offspring surviving to 12 months old. Further details of the study aims and design are available (www.ich.bris.ac.uk/alspacext/). Ethical approval was obtained from the study's ethics committee and local ethics committees.

Women completed the Edinburgh postnatal depression scale15 and the Crown Crisp experiential index16 as part of a series of postal questionnaires. We present here data for questionnaires completed at 18 weeks and 32 weeks of pregnancy and at 8 weeks and 8 months postpartum. The Edinburgh postnatal depression scale focuses on the cognitive and affective features of depression rather than somatic symptoms. It is the only self report scale that has been validated for use postnatally and during pregnancy. 17 18 The scale cannot in itself confirm a diagnosis of depression; however, a score above 12 is widely used to indicate probable depressive disorder. Validation of the scale showed that all those found to have definite major depression when interviewed, had scored above 12 on the scale. Use of this threshold gave an overall sensitivity of 86% and specificity of 78% for all forms of depression.15

Statistical methods
We calculated mean Edinburgh postnatal depression scale scores for all responders and those responding at all four time points. Although the scores were negatively skewed, the differences in scores were symmetric and normal enough for analysis with paired t tests. The 95% confidence intervals for the differences in the mean values were corrected for multiple (six) comparisons. We plotted frequency histograms of total scores for each period and compared changes in symptom score between 18 weeks and 32 weeks of pregnancy with changes between 32 weeks of pregnancy and 8 weeks postpartum using a paired t test. Mean scores for each item of the Edinburgh postnatal depression scales at each time point were plotted to compare the frequency with which each symptom was reported. We repeated the analyses on the data from the Crown Crisp experiential index depression subscale to investigate whether a different scale produced any substantial differences in results.

We divided the cohort between probable cases of depression and probable non-cases at each time point using a threshold of 12/13 on the Edinburgh postnatal depression scale. We then compared changes across this threshold from 18 weeks to 32 weeks of pregnancy and 32 weeks of pregnancy to 8 weeks postpartum. We made a simplifying assumption that the two groups were independent, although some of the women would have been common to both groups. Under this assumption, using a normal approximation to the binomial distribution, we derived a confidence interval for the difference in the proportion of women rising above the threshold for probable depression between each time point.


    Results
Top
Abstract
Introduction
Participants and methods
Results
Discussion
References

Of the 13 799 eligible mothers, 12 059 (87%) completed at least one of the four questionnaires and 9028 (65%) completed all four. Table 1 shows the mean Edinburgh postnatal depression scale scores for each period. Mean scores were higher in pregnancy than postnatally, with a peak at 32 weeks of pregnancy of 6.72 (SD 4.94) and a lowest value at 8 months postpartum (5.25 (4.61)). The mean change in depression score from that at 18 weeks of pregnancy was -0.097 (95% confidence interval -0.18 to -0.01, P=0.025) at 32 weeks of pregnancy, 0.78 (0.69 to 0.88, P<0.001) at 8 weeks postpartum, and 1.37 (1.27 to 1.46, P<0.001) at 8 months postpartum. Mean change in score was 0.88 (0.79 to 0.97, P<0.001) between 32 weeks of pregnancy and 8 weeks postpartum, 1.46 (1.37 to 1.56, P<0.001) between 32 weeks of pregnancy and 8 months postpartum, and -0.58 (-0.50 to -0.67, P<0.001) between 8 weeks and 8 months postpartum. Women who did not complete all four questionnaires had higher depression symptom scores than women who completed all four. The mean depression scores were therefore higher when partial responders were included (table 1).


                              
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Table 1. Edinburgh postnatal depression score during pregnancy and after childbirth

There was a small rise in depression symptom score during pregnancy (mean change 0.10; SE 0.043) and a small drop after childbirth (-0.88; 0.047). These changes were significantly different (difference 0.98, 95% confidence interval 0.83 to 1.13; P<0.001).

Table 2 shows the cumulative frequency of women with increasing Edinburgh postnatal depression scores at the four time points. The distribution did not differ between the time points.


                              
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Table 2. Cumulative number (percentage) of women with various Edinburgh postnatal depression scores at each time point.

Table 3 gives the scores for each item in the questionnaire. A similar pattern was seen at all four time points, but question 3 (I have blamed myself unnecessarily when things went wrong) was rated higher at 18 weeks of pregnancy that at other times and question 6 (things have been getting on top of me) was rated lower at 8 months postpartum than at other times.


                              
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Table 3. Mean score for Edinburgh postnatal depression scale items at each time point among 9028 women with complete data. (Maximum score for each question is 3)

When we repeated the above analyses using the Crown Crisp experiential index depression subscale there was no substantial differences in the findings.

The proportion of women with probable depression (Edinburgh postnatal depression score >= 13) was 11.8% at 18 weeks of pregnancy, 13.5% at 32 weeks of pregnancy, 9.1 % at 8 weeks postpartum, and 8.1% at 8 months postpartum (table 1). In all, 147 (1.6%) women had probable depression at all four time points and 6771 (75%) scored below the threshold at all time points; 436 (4.8%) had probable depression at 32 weeks of pregnancy only and 240 (2.7%) at 8 weeks postpartum only.

Of the 7966 women who were below the threshold for probable depression at 18 weeks of pregnancy, 673 (8.4%) were above the threshold at 32 weeks of pregnancy. Of the 7806 below the threshold for probable depression at 32 weeks of pregnancy, 410 (5.3%) were above the threshold at 8 weeks postpartum. There were 253 (3.2%) fewer women newly rising above the threshold for probable depression after childbirth than during pregnancy (95% confidence interval 2.4% to 4.0%).


    Discussion
Top
Abstract
Introduction
Participants and methods
Results
Discussion
References

We found that mothers have higher scores on the Edinburgh postnatal depression scale in pregnancy than postnatally and that the distribution of total scores and individual symptoms did not differ before and after childbirth. These data suggest that depression is no more likely after childbirth than it is after events during pregnancy.

Validity of instrument
Self report instruments do not provide a clinical diagnosis of depression. Some mothers scoring above the threshold will not have a depressive illness and some below the threshold will. However, a validation study found that a score of >= 13 gave the best estimate of prevalence of depression.15 This threshold may overestimate depression during pregnancy.17 However, even if we used a higher threshold in pregnancy than postnatally, depression was still common during pregnancy. Furthermore, the proportion of women rating themselves as severely depressed was similar before and after childbirth. We found no evidence that the question asking whether the woman feared she might harm herself was misinterpreted or overrated during pregnancy, despite suggestions that this could happen.19

Patterns of depression
We found no evidence to support the existence of a subgroup of women with a specific type or severity of symptoms. It has been suggested that a small subgroup of women with postnatal depression have abnormal thyroid function leading to depressed mood.20 Women who did not respond at all time points had higher depression scores, and the non-responders probably included some of the most depressed women. Our results may therefore be biased by selective non-response among women with severe postnatal depression. Another explanation for our lower postnatal scores is that incidence of depression may peak at a time not measured in this study. Our data support research suggesting that there is no difference in the pattern of symptoms of depression during pregnancy or postnatally. Thus, postnatal depression does not seem to be a distinct syndrome.

The scales that we used were developed using only the core symptoms of depression because they are applicable to different contexts. Women's experience of depression during pregnancy and after childbirth, however, may be very different. Childbirth is an important biological, social, and psychological event.

Although caution is needed when equating self report data with a clinical diagnosis of depression, our data suggest that childbirth is less likely than the events of pregnancy to be followed by depression in women who are not depressed, and more likely to be followed by improvement in women who are depressed. The fall in probable cases of depression after childbirth has been reported in a study using this dataset and examining change and stability in depression using latent variable modelling.21 However, there is some evidence that childbirth may be a non-specific stressor for depression in most women and a specific stressor in a subgroup of women.22 We will be able to test this hypothesis by following mothers through to their next pregnancy.

Implications
The consequences of antenatal depression are not well understood. Psychopathology during pregnancy may have an important effect on the uterine environment,14 and research is urgently needed into the consequences for the child of antenatal depression.

It is also important to study the potential benefits of screening for, and treating, depression during pregnancy. Although there are concerns about the widespread use of antidepressants during pregnancy, the benefits may outweigh the risks for women with severe depression. Non-pharmacological interventions that have been found effective in mild to moderate depression23 could be evaluated for treating depression during pregnancy.24 Our results show depression during pregnancy is more common than postnatal depression. Offering treatment may be important for both the mother and the future wellbeing of the child and family.


What is known on this topic

Postnatal depression is common

Recognising and treating depression is emphasised in postnatal care

Depression is also common in pregnancy

What this study adds

Self reported symptom scores for depression are higher in pregnancy than postnatally

The severity and nature of depressed mood does not differ before and after childbirth

More mothers have scores that rise above a threshold for probable depression during pregnancy than after childbirth



    Acknowledgments

We thank the mothers and fathers who took part and the midwives for their cooperation and help in recruitment. The study team comprises interviewers, computer technicians, laboratory technicians, clerical workers, research scientists, volunteers, and managers, who continue to make the study possible.

Contributors: JE wrote the paper and planned the data analyses, JH analysed the data, and HF planned the analyses and commented on the final draft of the paper. SO contributed to writing the paper and commented on the final draft. JG designed the study, advised on data analysis, and commented on the final draft. The ALSPAC study team designed the study and collected and entered the data. JE will act as guarantor.

    Footnotes

Funding: Medical Research Council, Wellcome Trust, Department of Health, Department of the Environment, and various charitable organisations and commercial companies. The ALSPAC study is part of the WHO initiated European longitudinal study of pregnancy and childhood.

Competing interests: None declared.


    References
Top
Abstract
Introduction
Participants and methods
Results
Discussion
References

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(Accepted 19 April 2001)

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Rapid Responses:

Read all Rapid Responses

Higher levels of depressed mood in pregnancy is not news
Carol Henshaw
bmj.com, 3 Aug 2001 [Full text]
Depression during pregnancy
Lisa Valentine
bmj.com, 6 Aug 2001 [Full text]
Higher Rate of depression in pregnancy?
Narayana Reddy Murali Jagadisha, et al.
bmj.com, 9 Aug 2001 [Full text]
Caution about the difference in depressed mood between pregnancy and after childbirth
J L Onwude
bmj.com, 10 Aug 2001 [Full text]
Depressed mood during pregnancy and following childbirth
Nazar N Amso
bmj.com, 14 Aug 2001 [Full text]
Depressed mood during pregnancy is not new and is associated with pre-eclampsia
Katharina Dalton
bmj.com, 16 Aug 2001 [Full text]
Do higher scores for depressed mood in pregnancy mean more Depression in pregnancy?
Sandra A Elliott
bmj.com, 17 Aug 2001 [Full text]
Cohort study of depressed mood during pregnancy and after childbirth
M R Oates, et al.
bmj.com, 17 Aug 2001 [Full text]
Optimising Use of Perinatal Mood Assessments
Julia Lappin
bmj.com, 17 Aug 2001 [Full text]
Depressed mood during pregnancy
Dietmar Fuchs
bmj.com, 24 Aug 2001 [Full text]
Cohort study of depressed mood in pregnancy and childbirth
John Sheehan, et al.
bmj.com, 24 Aug 2001 [Full text]
Focusing on Ante-natal depression
Thomas Nichols
bmj.com, 24 Aug 2001 [Full text]
A question of specificity of The Edindurgh scale
Brian Harris, et al.
bmj.com, 31 Aug 2001 [Full text]
birth experience
Christina Hurst-Prager
bmj.com, 2 Oct 2001 [Full text]
Profile of Antenatal Depression
Sue Lamerton
bmj.com, 18 Dec 2001 [Full text]
dead link
Thorsten Schumann
bmj.com, 31 Aug 2004 [Full text]
Re: dead link
Jonathan Evans
bmj.com, 31 Aug 2004 [Full text]
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