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Results of previous studies on the relation between birth weight and
risk of type 1 diabetes have been inconsistent. By linking two
nationwide registries, Stene et al (p 889) designed a large cohort
study in which all births in Norway (over a 25 year period) were
followed with respect to type 1 diabetes. Their results show a positive
association across a wide range of birth weights, with an estimated
increment in incidence of 1.7% per 100 g increase in birth weight.
This indicates that birth weight may be a rough indicator of some other
perinatal factor that is directly related to the risk of type 1 diabetes. It is not clear whether the observed association is causal or not.