Continuous infusions of amphotericin B deoxycholate reduce toxicity

Amphotericin B is the mainstay of treatment for many mycoses. A deoxycholate formulation has been used for decades despite its toxicity. The toxicity can be reduced by combining the drug with lipids, but this is costly. Eriksson et al (p 579) performed a randomised open study with 80 patients and showed that a continuous infusion of amphotericin B reduced toxicity in a manner similar to that reported for liposomal amphotericin B. The authors recommend using this method whenever practicable.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to StumbleUpon StumbleUpon   Add to Technorati Technorati    What's this?

Access jobs at BMJ Careers
Whats new online at Student BMJ