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Kaye et al (p 460) used the UK GP research database to conduct a time
trend analysis of children diagnosed with autism over the period
1988-99. They found that the risk of autism in 2-5 year old boys
increased from 8 per 10 000 boys in 1988 to 29 per 10 000 boys in
1993. MMR vaccine coverage was 95% throughout this period. The authors
conclude that there is no correlation between the prevalence of MMR
vaccination and the rapid increase in the risk of autism over time
because if MMR was a major contributing factor, the risk of autism in
successive birth cohorts would be expected to stop rising within a few
years of the vaccine being in full use.