HbA_1c concentration predicts mortality in whole population

Glycated haemoglobin concentration is known to predict cardiovascular risk in diabetic people, but it is unclear whether there is a threshold for the effect. Khaw et al (p 15) studied men in the Norfolk cohort of the European Prospective Investigation into Cancer and Nutrition to determine the effect of glycated haemoglobin in the whole population. They found that glycated haemoglobin concentration not only largely accounts for the increase in risk of death associated with diabetes but predicts mortality across the whole population distribution. The authors suggest that preventive efforts should consider lowering the concentration in the whole population through modification of lifestyle.

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Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of European Prospective Investigation of Cancer and Nutrition (EPIC-Norfolk)

Kay-Tee Khaw, Nicholas Wareham, Robert Luben, Sheila Bingham, Suzy Oakes, Ailsa Welch, and Nicholas Day
BMJ 2001 322: 15. [Abstract] [Full Text] [PDF]