Table 3. Change from baseline in score on 11 item cognitive subscale of Alzheimer's disease assessement scale at six months according to apolipoprotein E genotype No of copies of E4 allele Placebo group Galantamine groups P value No of patients* Mean (SE) change No of patients* Mean (SE) change Two 27 5.1 (1.1) 48  1.5 (0.7) 0.0001 One 67 1.9 (0.6) 138  1.0 (0.5) 0.0008 None 56 2.1 (0.9) 78  1.7 (0.7) 0.0006 * The low patient numbers reflect the fact that many patients did not give informed consent for apolipoprotein E genotyping.