Diabetic patients with hyper- tension benefit from dual blockade of renin-angiotensin system

Over half of patients with type 2 diabetes have or develop hypertension. There seems to be no distinct cut off level regarding the subsequent risk related to blood pressure in these patients, but those with microalbuminuria are particularly at risk. The study by Mogensen et al (p 1440) introduces a new concept in the management of hypertension in patients with type 2 diabetes with microalbuminuria and possibly also management of essential hypertension. Dual blockade of the renin-angiotensin system significantly reduced blood pressure in these high risk patients.

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Relevant Article

Randomised controlled trial of dual blockade of renin-angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: the candesartan and lisinopril microalbuminuria (CALM) study

Carl Erik Mogensen, Steen Neldam, Ilkka Tikkanen, Shmuel Oren, Reuven Viskoper, Richard W Watts, and Mark E Cooper
BMJ 2000 321: 1440-1444. [Abstract] [Full Text] [PDF]