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Most infants experience some local reactions to primary
vaccinations, which may discourage parents from further immunisations. Two needle sizes are commonly used in general practice: the 25 gauge,
16 mm, orange hub needle and the 23 gauge, 25 mm, blue hub needle.
Diggle and Deeks (p 931) conducted a randomised controlled trial to
compare the rates of local reactions with these two needles after the
third immunisation. The results show a clear benefit of using the
longer needle (local reaction rates 62%) rather than the shorter
needle (84%). The authors conclude that the results are important to
vaccine manufacturers, many of which supply the shorter needle within
vaccine packs.