Long allele  oestrogen receptor genotype may increase risk of coronary artery disease

The risk of coronary artery disease has been linked to concentrations of oestrogen and the density of oestrogen receptors as well as a host of other factors. Kunnas et al (p 273) carried out a case control study in 119 patients with myocardial infarction to determine the effect of the  oestrogen receptor genotype on the severity of the infarction. Compared with patients with short alleles, those with long alleles for the  oestrogen receptor were at a greater risk of myocardial infarction (OR=11.4), with greater coronary narrowing and more complicated lesions. They speculate that carriers of long repeat variants have lower expression of the oestrogen receptor gene and benefit less from the cardiovascular protective effect of oestrogen receptors.

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Association of polymorphism of human  oestrogen receptor gene with coronary artery disease in men: a necropsy study

Tarja A Kunnas, Pekka Laippala, Antti Penttilä, Terho Lehtimäki, and Pekka J Karhunen
BMJ 2000 321: 273-274. [Full Text] [PDF]