Intranasal midazolam effectively treats febrile seizures in children
Midazolam, a water soluble benzodiazepine, has been used both
intravenously and intramuscularly to treat epilepsy. Lahat et al
(p 83) describe a prospective randomised study comparing midazolam given intranasally with diazepam given intravenously to treat prolonged febrile seizures in 47 children. Seizure control was faster with intravenous diazepam, but intranasal midazolam was equally effective and safe. The time to cessation of seizures was
faster with intranasal midazolam than with intravenous diazepam. Intranasal midazolam could be used in general practice and at home.
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- Comparison of intranasal midazolam with intravenous diazepam for treating febrile seizures in children: prospective randomised study
- Eli Lahat, Michael Goldman, Joseph Barr, Tzvi Bistritzer, and Matithyahu Berkovitch
BMJ 2000 321: 83-86.[Abstract] [Full Text] [PDF]
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