Gene mutation found that might predispose to type 2 diabetes
Gene mutation HFE C282Y (present in 10% of the UK population)
predisposes to haemochromatosis, which commonly leads to type 2 diabetes. Salonen et al (p 1706) therefore studied over 500 middle
aged Finnish men over four years to see whether carrier status for the
C282Y mutation predicted the development of type 2 diabetes. Four
(11%) of the carriers and 23 (5%) of the non-carriers developed
diabetes. The authors suggest that screening for C282Y status might
help prevent some cases of diabetes.
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- Role of C282Y mutation in haemochromatosis gene in development of type 2 diabetes in healthy men: prospective cohort study
- Jukka T Salonen, Tomi-Pekka Tuomainen, and Kimmo Kontula
BMJ 2000 320: 1706-1707.[Extract] [Full Text] [PDF]
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