Adding salmeterol is more effective than increasing inhaled steroids in symptomatic asthma
The 
2 agonist debate in the early 1990s
overshadowed the introduction of salmeterol, resulting in greater
emphasis on higher doses of inhaled steroids for control of asthma. On
p 1368 Shrewsbury et al report on a meta-analysis of the benefit of
adding salmeterol compared with increasing the dose of steroids. The
addition of long acting bronchodilator resulted in greater benefit for
lung function, better control of symptoms, and reduced use of rescue medication compared with an increased dose of steroids. Additionally, fewer patients experienced exacerbations.
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- Meta-analysis of increased dose of inhaled steroid or addition of salmeterol in symptomatic asthma (MIASMA)
- Stephen Shrewsbury, Stephen Pyke, and Mark Britton
BMJ 2000 320: 1368-1373.[Abstract] [Full Text] [PDF]
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