Table A

Table B

References
 

Table  A  Summary of published studies on vaccination coverage for rubella in Greece carried out before epidemic of 1993  
 

Reference	Year and place	Study population	Methodological rating*	Age of children	Sample size	Immunisation coverage for rubella (%)†
w5	1979: Districts of Xanthi and Evros	Birth registries	A	5 years	119	10
					227	4
	1979: District of Iraklion, Crete
w6	1980	Attendance at several health services	B	2-10 years	340	12
	Athens and rest of Greece
w7	1980	Inpatients in hospital of Ioannina and attendance at day care centres	D	6 months-12 years	269	0
	Region of Ipiros
w8	1980-1	Primary schoolchildren	A	6 years	600	5
	City of Thessaloniki
w12	1986	Household survey	A	2.5-5.5 years	111	25
	Perama, Piraeus
w13	1987: Island of Lefkada	Attendance at several health services, and primary schoolchildren	D	5-12 years	564	33
					758	12
	1987: Town of Sitia, Crete
w14	1988	Attendance at day care centres	D	Not stated (preschool age)	372	35
	Athens
w15	1988	Inpatients in Children's Hospital of Athens	B	2-6 years	257	39
	Athens and rest of Greece
w16	1988	Primary schoolchildren	C	6-12 years	921	23
	Rafina, Attiki
w17	1988-9	Secondary school students (girls)	B	17 years	196	2
	Area of Thiva
w18	1988-9	Secondary school students	D	11-17 years	1490	4
	Area of Koufalia, Thessaloniki
w19	1990	Primary schoolchildren	A	6 years	95	60
	Island of Thasos			12 years	113	52
w20	1990	Attendance at day care centres	D	1-5 years	202	68
	City of Ioannina
w21	1990: Island of Samos urban areas	Not stated	D	6-12 years	572	42
					428	45
	1990: Island of Samos rural areas
w22	1990-1	Inpatients in children's hospital of Athens	B	6-14 years	202	46 (by 6 years of age)
	District of Attiki
w23	1991-2	Primary and secondary schoolchildren	B	4-14 years	85	41
	District of Melambes, Crete
w24	1992	Attendance at the outpatient department of the Hospital of Katerini	D	0-4 years	358	35
	City of Katerini			5-9 years	629	61-63
				10 -14 years	682	43-52
w25	1992	Not stated	D	Not stated (preschool and school age)	7566	37
	District of Rodopi

*A: adequate documentation of methods used and sample representative of general population; B: adequate documentation of methods used and sample not representative of general population; C: inadequate documentation of methods used and sample representative of general population; D: inadequate documentation of methods used and sample not representative of general population.

†Results most comparable with those of other studies are included.1

Table B  Summary of published serological studies on rubella immunity in Greece carried out before epidemic of 1993
 

Reference	Year and place	Study population	Serological assay	Methodological rating*	Age of subjects	Sex of subjects	Sample size	Percentage susceptible to rubella†
w26	1966	Army recruits	Neutralisation test	A	20-25 years	Male
	Greece:
	Total						1200	17
	Urban areas						387	14
	Rural areas						287	26
	Greater Athens						266	8
w27	1971	Primary schoolchildren	Haemagglutination inhibition test	D	10-12 years	Male and female	128	16
	Nea Mihaniona, Thessaloniki
w28	1971-5	Pregnant women tested at the virology laboratory of the Democritos research centre, Athens	Haemagglutination inhibition test	B	Not stated (childbearing age)	Female	1447	12
	Greater Athens
w29	1975	Healthy individuals tested at the serological laboratory of the Alexandra hospital, Athens	Haemagglutination inhibition test	B	20-40 years	Female	503	10
	Athens
w30	1977	Nurses at Children's Hospital, Athens	Not stated	D	Not stated	Female	94	4
	Athens
w31	1978	Women tested at the serological laboratory of the University of Thessaloniki	Haemagglutination inhibition test	B	Not stated (childbearing age)	Female	223	16
	Northern Greece
w32	1979	Secondary school students	Not stated	D	16-17 years	Male and female	Not stated	7
	Island of Salamis
w33	1980	Pregnant women tested at the serological laboratory of the Alexandra hospital, Athens	Haemagglutination inhibition test	B	25-30 years	Female	441	11
	Athens	Student nurses	Haemagglutination inhibition test	B	18-21 years	Female	559	11
w34	1980	Several sources	Haemagglutination inhibition test	D	21-45 years	Male and female	127	11
	Northern Greece
w35	1981	Pregnant women who attended the obstetrics outpatient department of the Alexandra hospital, Athens	Haemagglutination inhibition test	B	20-29 years	Female	100	17
	Athens
w36	1986	Women who delivered at the University Hospital of Patra	Enzyme linked immunosorbent assay	B	18-40 years	Female	107	23
	Area of Patra
w37	1984-9	Women tested at the serological laboratory of the Athens General Hospital (reference laboratory for rubella)	Haemagglutination inhibition test	B	Not stated (childbearing age)	Female
	Athens	Pregnant women					590	24
		Non-pregnant women					514	18
w38	1988-9	Pregnant women who attended the obstetrics outpatient department of the University Hospital of Patra	Not stated	D	16-42 years	Female	512	16
	Area of Patra
w17	1988-89	Secondary school students	Haemagglutination inhibition test	B	17 years	Female
	Area of Thiva	Total					196	19
		Inhabitants of Thiva (city)					134	13
		Inhabitants of villages					62	34
w39	1991	Secondary school students	Not stated	D	17 years	Female	521	14
	Distric of Ioannina
w40	1979-81	Secondary school students	Haemagglutination inhibition test	B	13-18 years	Female	2079	20
	Athens
	1984-9	Sudent nurses	Haemagglutination inhibition test	B	Not stated (childbearing age)	Female	1203	25
	Athens
	1990-1	Women tested at the serological laboratory of the Athens General Hospital (reference laboratory for rubella)	Haemagglutination inhibition test	B
	Athens	Pregnant women			25-35 years	Female	173	36
		Healthy individuals			20-40 years	Not stated	647	39
	1990-1	Student nurses	Haemagglutination inhibition test	B	17-20 years	Female	400	24
	Athens
w41	1989-93	Pregnant women who attended the obstetrics department of the General Hospital of Kalamata	Enzyme linked immunosorbent assay	D	Not stated	Female	1200	20
	Area of Kalamata

*A: adequate documentation of methods used and sample representative of the general population; B: adequate documentation of methods used and sample not representative of the general population; C: inadequate documentation of methods used and sample representative of the general population; D: inadequate documentation of methods used and sample not representative of the general population;

†The results which are most comparable with those of other studies are included.
 
References:  All the following references are in Greek

1. Tenth annual therapeutic update, April 1977. Ann Clin Paediatr Univ Atheniensis 1978;25(suppl):104-35.
2. Thirteenth annual therapeutic update, April 1980. Ann Clin Paediatr Univ Atheniensis 1981;28(suppl):116-43.
3. Deligiorgis D. Socio-economic characteristics and health problems of children aged 0-5 years in the area of Greater Athens. [Dissertation]. Athens: Institute of Child Health, 1978:52-4.
4. Preventive vaccination. Athens: Ministry of Health and Social Security, Directorate of Public Health, Mar 19, 1984. (Document 3081.)
5. Patrona Z. Health problems of preschool children in two areas of Greece with different infant mortality. [Dissertation.] Athens: Institute of Child Health, 1984.
6. Valassi-Adam E, Maragos C, Manolaki A, Matsaniotis N. Immunization 1980. Ann Clin Paediatr Univ Atheniensis 1981;28:202-8.
7. Tziakos M. Stafilakis K, Pantelakis S, Katsougiannopoulos V, Lapatsanis P. Immunization uptake of children aged 6 months to 12 years in the area of Epiros. Proceedings of the 19th panhellenic paediatric conference, Athens, Greece, 13-14 Jun, 1981. (No 81.)
8. Hatzipantelis S, Hrisohoou-Dalesi Z. Epidemiological survey on immunization. Paediatriki 1982;45:201-4.
9. Compulsory vaccination schedule. Athens: Ministry of Health and Social Security, Directorate of Public Health, Jan 27, 1987. (Document A1/766).
10. Vaccination against measles, mumps, and rubella. Athens: Ministry of Health and Social Security, Directorate of Public Health, Jan 11, 1989. (Document A1/76/ circular 2).
11. Ministry of Health and Social Security. National immunization programme for Greece. Athens, Greece: MHSS, 1991.
12. Panagiotopoulos T. Health of preschool children. Morbidity and primary health care needs. Athens, Greece: Foundation for Research in Childhood, 1991:124-36.
13. Fotiou K, Raftopoulou O, Niarchou A, Papadaki E. Immunization in Greek provinces. Ann Clin Paediatr Univ Atheniensis 1988;35:210-7.
14. Antoniadou-Koumatou I, Adam E. Immunization. [Letter.] Arch Hellenic Med 1989;6:156-7.
15. Maragos C, Papadeas D, Antoniadou-Koumatou I, Valassi-Adam E. Immunization 1988. Arch Hellenic Med 1989;6:140-2.
16. Livadas N, Delissavas M, Karagianopoulou N, Adam G. Immunization status in school-age children in the area of Rafina. Paediatriki 1989;52:274-82.
17. Papageorgiou V, Kougialis S, Adamopoulou M, Papagrigoriou M, Adam E. Rubella immunity in female students in Thiva. [Letter.] Arch Hellenic Med 1991;8:446-7.
18. Metaxas N, Hatzimihail E, Balitas A, Leftheriotou-Livarda S, Papadopoulos I, Bonias S, et al. Contribution of the health centre of Koufalia in the achievement of full immunization in 1490 students of secondary school. Proceedings of the 30th panhellenic paediatric conference, Lemessos, Cyprus, Jun 13-4:1992. (No 105.)
19. Apostolidis G, Ellinas D, Lambropoulou H. Study of immunization status in the 1st and 6th grade of primary school in Thassos. Paediatriki 1991;54:337-44.
20. Vrionis G, Galanakis M, Haralambopoulos K. Immunization in Epiros: epidemiological data. Proceedings of the 29th panhellenic paediatric conference, Heraklion, Greece, May 25-6:1991. (No 215.)
21. Theodosi A, Grammatikos E, Tourvas S, Stergiopoulos I, Gionis D. Study of immunization coverage of children in the island of Samos. Proceedings of the 29th panhellenic paediatric conference, Heraklion, Greece, May 25-6:1991. (No 127.)
22. Siahanidou T, Drakonaki S, Garoufi A. Giakouvis A, Iasonidis M, Parha S, et al. Immunization status of hospitalized children. Paediatriki 1993;56:503-10.
23. Lionis H, Bathianaki M, Lentari E, Hatzigeorgiou M, Triantafyllou T, Filalithis A. Assessment of immunization needs of primary and secondary school children in a rural area of Crete. Proceedings of the 6th medical conference of Crete, Rethymno, Greece. 1992;A:38-42.
24. Karavergos P, Nanas H, Haidopoulou K, Karabatakis N, Missailidis T, Velentza P. Immunization with the DTP-DT-Sabin and the MMR-measles-mumps-rubella vaccines in the city of Katerini. Proceedings of the 31st panhellenic paediatric conference, Chalkidiki, Greece, Jun 4-6:1993. (No 338.)
25. Pantazi-Hatziconstantinou A, Lepidas G, Karanikolaou E, Hatziconstantinou N, Iatropoulos I. Programme of compulsory vaccines. Implementation-prospects. Study of 7566 children in the District of Rodopi. Proceedings of the 31st panhellenic paediatric conference, Chalkidiki, Greece, Jun 4-6:1993. (No 125.)
26. Papaevangelou G. Serologically detected immunity to rubella among Greek adults. [Dissertation.] Athens: University of Athens, 1967.
27. Keramida-Karamitsou P, Edipidis T. Frequency of rubella antibodies among children 5-12 years old. Acta Microbiologica Hellenica 1972;17:109-15.
28. Plasara M, Havele P. The serological diagnosis of rubella during pregnancy. Iatriki 1977;31:500-4.
29. Patramani I, Mitrogianni D, Petropoulou A, Pavlatou M. Detection of antibodies against rubella virus. Acta Microbiologica Hellenica 1976;21:10-21.
30. Stavrinadis H, Plassara M, Alexiou D. Frequency of detected antibodies against rubella and cytomegalovirus among nurses. Proceedings of the 16th panhellenic paediatric conference, Thessaloniki, Greece, Jun 17-8:1978. (No XXIII.)
31. Kiriazopoulou-Dalaina V. Rubella epidemic 1978. Hellenic Med 1978;47:408-14.
32. Plasara M, Stavrinadis H, Alexiou D, Papadatos K, Kritsikis S, Villiotou-Kritsiki F, et al. Frequency of detected antibodies against rubella and cytomegalovirus among 1000 students aged 7-17 years in the Island of Salamis. Proceedings of the 18th panhellenic paediatric conference, Nicosia, Cyprus, Jun 24-6:1980. (No 59.)
33. Alexandrou-Iliadi ME, Patramani I, Stefanou T, Pavlatou M. The immune status of young adult women to rubella virus. Acta Microbiologica Hellenica 1981;26:269-74.
34. Bryden AS, Mavromichalis I, Hutchinson DN, Hudson P, Dodd B, Dematia M, et al. Incidence of rubella antibodies in the population of Northern Greece. Acta Microbiologica Hellenica 1981;26:59-68.
35. Tsoukalos S, Tzigounis B, Lazaris D, Mihalas S, Aravantinos D, Kaskarelis D. Detection or rubella antibodies by the hemoagglutination test in pregnant women. Iatrika Chronika 1982;5:465-71.
36. Papapetropoulou M, Kondakis X. Immunological and epidemiological investigation of pregnant women for antibodies against rubella. Iatriki 1987;52:535-7.
37. Karabogia-Karafyllidi P, Vagiakou-Voudri E, Magoura S, Kanakaki S, Polychronopoulou-Karakatsani A. Assessment of the antibody level against rubella in women of child bearing age. Proceedings of the 17th panhellenic medical conference, Athens, Greece, May 7-11:1991. (No 427.)
38. Arkoulis T, Papapetropoulou M, Karamitsou G, Gatopoulou K, Markantes K, Tzigounis B. Antibodies against toxoplasma gondii and rubella in pregnant women in Southwestern Greece. Proceedings of the 17th panhellenic medical conference, Athens, Greece, May 7-11:1991. (No 113.)
39. Prevalence of hepatitis B surface antigen and of antibodies against rubella and toxoplasma gondii in female students in the District of Ioannina. Proceedings of the 18th panhellenic medical conference, Athens, Greece, May 12-6:1992. (No 101.)
40. Karabogia-Karafyllidi P, Vagiakou E, Mandrouka B, Kafasi N, Polychronopoulou-Karakatsani K. Seroepidemiology of rubella in a healthy population during the years 1990-91. Proceedings of the 2nd panhellenic conference of virology, Athens, Greece, 1992:130-6.
41. Georgiopoulos A, Haralambous H, Soumakis K. The importance of immunization of women susceptible to rubella. Proceedings of the 8th panhellenic conference of perinatal medicine, Athens, Greece. Apr 16-7;1994:187-9.
42. Papaioannou A. Epidemiological study of seven childhood infections from school data in the area of Athens. Proceedings of the Academy of Athens 1963;38:531-46.
43. Bartsokas S, Akilas V. Rubella in pregnancy and congenital anomalies of the children. Nosocomiaka Chronika 1953;14:62-4.
44. Choremis K, Kasimos C, Ioannidis T, Nihogiannopoulos I, Alexopoulos K. Rubella embryopathy after rubella in pregnancy. Ann Clin Paediatr Univ Atheniensis 1955;2:201-8.
45. Kiriazopoulou-Dalaina V, Frantzidou-Adamopoulou F, Diza-Matavtsi E, Souliou-Simeonidou E, Papaioannou IK. Congenital infections and laboratory diagnosis (findings in the twelve-year period 1974-1985). Galenus 1987;29:234-42.
46. Kremenopoulos G, Drosou V, Parisis P, Kasimos C. A case of congenital rubella. Pediatrica Chronika 1980;9:197-202.
47. Hatziioannidis K, Thomaidis K, Varlamis G, Nenopoulos E, Sklavounou-Tsouroutsoglou S. A case of congenital rubella with multiple manifestations. Pediatrika Chronica 1984;13:150-4.
48. Kiriazopoulou-Dalaina V, Franntzidou-Adamopoulou F, Doutsios I, Diza-Matavtsi E, Papapanagiotou I. Laboratory diagnostic problems during a rubella epidemic. Acta Microbiologica Hellenica 1986;31:41-9.
49. Skoutari M, Kallergi K, Koupari G, Zaridi K, Kremastinou J. Laboratory testing for congenital infections in neonates and infants with clinical manifestations. Proceedings of the 14th panhellenic medical conference, Athens, Greece, May 3-7:1988. (No 425.)
50. Vaccination of students. Athens: Ministry of Health and Social Security, Directorate of Public Health, Dec 12, 1983. (Document A1/12605).

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