BMJ 1999;319:731-734 ( 18 September )

Papers

Decision aids for patients facing health treatment or screening decisions: systematic review

Annette M O'Connor, professor a,  Alaa Rostom, gastroenterologist a,  Valerie Fiset, clinical nurse specialist b,  Jacqueline Tetroe, research associate a,  Vikki Entwistle, senior research fellow c,  Hilary Llewellyn-Thomas, professor d,  Margaret Holmes-Rovner, professor e,  Michael Barry, chief, general medicine unit f,  Jean Jones, consumer health advocate g. 

a University of Ottawa School of Nursing and Faculty of Medicine, Loeb Health Research Institute Clinical Epidemiology Unit, Ottawa Hospital, Civic Campus, Ottawa, Ontario, Canada K1Y 4E9, b Sisters of Charity of Ottawa Health Services, Ottawa, Ontario, Canada, c Health Services Research Unit, University of Aberdeen, Aberdeen, Scotland, d University of Toronto, Institute for Clinical Evaluative Sciences, North York, Ontario, Canada, e Department of Medicine, Michigan State University, East Lansing MI, USA, f General Medicine Unit, Massachusetts General Hospital, Boston, MA, USA, g Dundas, Ontario, Canada

Correspondence to: A O'Connor aoconnor{at}LRI.CA

    Abstract
Top
Abstract
Introduction
Methods
Results
Discussion
References

Objective: To conduct a systematic review of randomised trials of patient decision aids in improving decision making and outcomes.
Design: We included randomised trials of interventions providing structured, detailed, and specific information on treatment or screening options and outcomes to aid decision making. Two reviewers independently screened and extracted data on several evaluation criteria. Results were pooled by using weighted mean differences and relative risks.
Results: 17 studies met the inclusion criteria. Compared with the controls, decision aids produced higher knowledge scores (weighted mean difference=19/100, 95% confidence interval 14 to 25); lower decisional conflict scores (weighted mean difference=-0.3/5, -0.4 to -0.1); more active patient participation in decision making (relative risk = 2.27, 95% confidence interval 1.3 to 4); and no differences in anxiety, satisfaction with decisions (weighted mean difference=0.6/100, -3 to 4), or satisfaction with the decision making process (2/100,-3 to 7). Decision aids had a variable effect on decisions. When complex decision aids were compared with simpler versions, they were better at reducing decisional conflict, improved knowledge marginally, but did not affect satisfaction.
Conclusions: Decision aids improve knowledge, reduce decisional conflict, and stimulate patients to be more active in decision making without increasing their anxiety. Decision aids have little effect on satisfaction and a variable effect on decisions. The effects on outcomes of decisions (persistence with choice, quality of life) remain uncertain.

    Introduction
Top
Abstract
Introduction
Methods
Results
Discussion
References

Some medical decisions are complex because the evidence on outcomes is uncertain or the options have different risk-benefit profiles that patients value differently. 1 2 Practice guidelines for these difficult decisions recommend that patients understand the probable outcomes of options; consider the personal value they place on benefits versus risks; and participate with their practitioners in deciding about treatment.3 Decision aids or shared decision making programmes have been developed as adjuncts to counselling from practitioners. Their efficacy has been described in general reports and reviews.4-6 We conducted a systematic overview of the trials of decision aids to determine whether they improved decision making and outcomes for patients facing treatment or screening decisions.

    Methods
Top
Abstract
Introduction
Methods
Results
Discussion
References

The search strategy is described in detail elsewhere.7 We searched the following electronic databases: Medline (1966-April 98); Embase (1980-November 98); PsycINFO (1979-March 98); CINAHL (1983-February 98); Aidsline (1980-98); CancerLit (1983-April 98); and the Cochrane Controlled Trials Register (1998, Issue 4). Additional studies were searched for in our personal files and the contents lists of Health Expectations (1998), Medical Decision Making (January-March 1986-January-March 1998), and Patient Education and Counselling (January 1995-February 1998).

We included randomised controlled trials comparing decision aids to controls or alternative interventions. Participants were 14 years and over deciding about screening or treatment options. Decision aids were defined as interventions designed to help people make specific and deliberative choices among options (including the status quo) by providing (at the minimum) information on the options and outcomes relevant to a patient's health. The aid may also have included information on the disease or condition; probabilities of outcomes tailored to personal health risk factors; an explicit exercise to clarify values; information on others' opinions; and guidance or coaching in the steps of decision making and communicating with others. We excluded studies involving hypothetical choices; decisions regarding lifestyle changes, entry to a clinical trial, or general advance directives; education programmes not geared to a specific decision; and interventions designed to promote compliance or to elicit informed consent for a recommended option.

Evaluation of outcomes depends on the framework used to develop the decision aids. 5 8-13 To ascertain whether the decision aids achieved their objectives, we examined a broad range of positive or negative effects on decision making processes and outcomes of decisions. Although the decision aids focused on diverse clinical decisions, many had similar objectives such as improving knowledge, satisfaction, and participation in decision making and reducing decisional conflict. Other outcomes included the choices patients selected, anxiety, and health related quality of life.

Two reviewers (VF, AR, or JT) screened each study and extracted data independently using standardised forms. Inconsistencies were resolved by discussion and consensus. Missing data were obtained from the authors when possible.

The results of the studies were described individually and pooled when similar measures were used. We used RevMan V3.114 to estimate a weighted treatment effect (with 95% confidence intervals). We used weighted mean differences for continuous measures and Mantel-Haenszel methods to calculate pooled relative risks for dichotomous outcomes. Heterogeneity was tested with a chi 2 test (alpha =0.10). If clinically and statistically appropriate, heterogeneous data were analysed with a random effects model.

    Results
Top
Abstract
Introduction
Methods
Results
Discussion
References

We identified 10 387 unique citations from the electronic databases and nine studies from personal files and contacts. Of these, 500 citations focused on patient decision making and 17 met our inclusion criteria.15-31

The decision aids focused on 11 screening or treatment decisions (see BMJ's website for details). All aids included information on the clinical problem in addition to information on the options and outcomes. Over half included outcome probabilities, examples of others, and guidance in the steps of decision making. A quarter included a values clarification exercise.

Compared with usual care (table 1), decision aids improved average knowledge scores for the options and outcomes by 13 to 25 points out of 100 (weighted mean difference=19, 95% confidence interval 14 to 25). Compared with simpler interventions, more intensive decision aids improved average knowledge scores by 0.9 to 6 points (weighted mean difference 3, 0.7 to 5).


                              
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Table 1. Effect of decision aids on patient's knowledge of options and outcomes

Decision aids had a positive impact on decisional conflict in three of four studies (table 2) with reductions ranging from 0.2 to 0.4 out of 5 (weighted mean difference=0.3, 0.1 to 0.4). When the subscales of decisional conflict were examined (data not shown), all studies showed that decision aids were better than usual care or simpler aids in improving patients' perceptions of "feeling informed." 19 25 26 In two of three studies, decisions aids also made patients feel clear about personal values and supported in decision making. 19 26 The uncertainty subscale improved decisional conflict in the short term but not the long term in one study,28 and in another the perceived effective decision subscale improved.19


                              
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Table 2. Effect of decision aids on decisional conflict

Three studies evaluated satisfaction with the decision making process and satisfaction with the decision using similar interventions, designs, and measures. 15 16 25 One study found that decision aids improved satisfaction with the decision making process,15 but the pooled difference was not significant (weighted mean difference=2, -3 to 7). There were no significant differences between usual care and decision aids in satisfaction with the decision in either the individual trials or in the pooled studies (weighted mean difference=0.6, -3 to 4). Two other studies that used different measures also found no significant differences in satisfaction with the decision. 24 28

Fourteen studies assessed the effect of decision aids on the decision made by the participants (table 3). In trials examining decisions about major surgery, decision aids reduced the preference for the more intensive treatment by 21-42% (relative risk=0.74, 95% confidence interval 0.6 to 0.9). In contrast, decision aids did not influence preferences for circumcision of newborn babies (0.96, 0.85 to 1.07).


                              
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Table 3. Effect of decision aids on patients' decisions

Decision aids significantly reduced preferences for prostate specific antigen testing (by 21-48%) in two studies but had no effect in another. There was significant heterogeneity when results were pooled, and the relative risk with a random effects model was not significant (0.83, 0.6 to 1.3). Preferences for screening for breast cancer genes and prenatal testing were not affected by decision aids in individual or pooled studies (1.08, 0.95 to 1.22).

Decision aids increased preferences for hepatitis B vaccine by 76% but did not affect decisions about dental surgery. Decisions regarding hormone therapy were not affected when more intensive methods were compared with simpler methods to aid decisions.

In three studies decision aids showed a consistent trend in increasing the proportion of participants assuming a more active role in decision making compared with usual case controls (pooled relative risk=2.27, 1.3 to 4). 18 19 25

We were unable to combine the results of some studies because of lack of information on standard deviations. One study found that decision aids significantly reduced the decline in quality of life after treatments for benign prostatic hypertrophy,15 but a study focusing on treatments for ischaemic heart disease showed no difference.16 Four studies showed that the use of decision aids did not affect patients' anxiety. 18 19 24 30 One study found that patients receiving a decision aid with detailed outcome descriptions and probabilities had more realistic expectations (accurate perceptions of the probabilities of outcomes) than those who did not have this information included.26

    Discussion
Top
Abstract
Introduction
Methods
Results
Discussion
References

Despite the variability in decisions, interventions, and measurement, the trials were consistent in showing that decision aids do a better job than usual care in improving patients' knowledge about options, reducing their decisional conflict, and stimulating patients to take a more active role in decision making without increasing their anxiety. Decision aids had a variable effect on decisions and virtually no effect on satisfaction. The effects on the outcomes of decisions (such as quality of life) are still uncertain. When compared with simpler versions, more intensive decision aids reduced decisional conflict, improved knowledge marginally, and had no different effect on satisfaction.

Knowledge, comfort, and empowerment
The largest and most consistent benefit of decision aids over usual care is better knowledge of options and outcomes. The 19% improvement in scores is clinically important because the scores of people in the usual care group were inadequate for informed decision making and they often made different decisions. These results suggest that doctors' usual methods may not be good enough for informing patients about these complex, value laden decisions. Patients need to comprehend the options and outcomes in order to consider and communicate the personal value they place on the benefits versus the harms.

Decision aids help patients feel more comfortable with their choices, as shown by the reduced decisional conflict scores. Patients uniformly feel more informed about options, and in some cases (notably primary care settings) feel clearer regarding personal values and supported in decision making. The improvement is one to two thirds of a standard deviation. Cross sectional studies suggest that this shift places more patients in the zone where they are more likely to follow through their decisions. However, the effect of reduced decisional conflict on persistence with choices needs to be established prospectively.

Decision aids increased active participation in decision making. The relative and absolute size of the effect was much greater in the Davison studies, 18 19 possibly because coaching was part of the interventions.

Altering choices
The variable effect of decision aids on patients' decisions may be due to several reasons. Firstly, most studies were underpowered to detect important differences. Secondly, some of the 11 options may have been underused at baseline and others overused. This would influence the direction of effect once patients become informed and involved in decision making. Thirdly, patients may react differently to the outcomes being considered in the different decisions. Some decisions may be driven predominantly by the probabilities of outcomes and others by the values for outcomes. For example, the aids seem to have a small effect on decisions about major surgical procedures. This may be because patients have inflated perceptions of the probability of benefit and do not understand the probabilities of risks and uncertainties in evidence of effectiveness. When given better knowledge of the outcomes and their associated probabilities, fewer patients may decide that the benefits outweigh the risks. In contrast, decision aids had little effect on circumcisions. This decision may be driven more by values and norms than by perceived probabilities of medical outcomes, as is suggested by the high rates of use in both arms of the trials.

Satisfaction
The studies showed no effect on satisfaction with decision making. This may because it is difficult to show improvements in satisfaction when control ratings are already quite high and when choices are inherently difficult because of competing benefits and risks. Furthermore, once the decision is made, people may find it more psychologically comforting to say that they are satisfied with it than to entertain doubts about what they chose.32

Further research
The small differences between simpler and more complex versions of decision aids indicate a need to establish the essential ingredients in decision aids and to identify the patients who are most likely to benefit from more complex versions.

There are several gaps in research. Few studies examined the effects on persistence with choices or health outcomes. We also know little about doctors' views about decision aids, the effect on patient-doctor interactions, and cost effectiveness. More trials are needed to gain a better understanding of what types of decision support work with which types of patients. Baseline predisposition toward choices, preference for participation in decision making, age, sex, ethnicity, and education may all have a bearing on the effectiveness of decision aids. Future reviews would be aided if investigators used standard search terms (such as "shared decision making") and gave structured reports of the composition of decision aids and comparison interventions. Moreover, people who develop and use decision aids need to reach a consensus on a minimum set of criteria for evaluating their effects.


What is already known on this topic

Patient decision aids or shared decision making programmes aim to help patients come to informed decisions

Studies of their effectiveness have often been small and have focused on a wide range of medical conditions

What this study adds

Decision aids are better than usual care in improving patients' knowledge, comfort, and participation in decision making without increasing anxiety

They have little effect on satisfaction and variable effect on patients' decisions

Compared with simpler versions, more detailed aids improve patients' comfort with decision making and marginally improve knowledge



    Acknowledgments

   Contributors: All authors contributed to the design of the protocol, the interpretation of results, and the revision and final approval of the final paper. AO'C led the team and JT coordinated the project. AO'C, MH-R, AR, VF, and JT pilot tested the data extraction forms. AR, VF, and JT screened studies and extracted data. AR, JT, and AO'C analysed the results. The Cochrane Consumers and Communication Review Group (editor Alex Jadad) provided peer review and advice regarding the research protocol. Maire O'Donnell from the University of Aberdeen Health Services Research Unit assisted with literature searching. AO'C is the study guarantor.

    Footnotes

Funding: The overview was supported by a group grant from the Medical Research Council of Canada. At the time of the study AO'C was funded by the Ontario Ministry of Health, VE held a special research fellowship from the Leverhulme Trust, and HL-T was a national health scholar funded by Health Canada's National Health Research Development Program.

Competing interests: None declared.

website extra: A table giving details of the studies included in the review is available on the BMJ's website www.bmj.com

    References
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Abstract
Introduction
Methods
Results
Discussion
References

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(Accepted 19 August 1999)

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  • Majumdar, S. R., McAlister, F. A., Furberg, C. D. (2004). From knowledge to practice in chronic cardiovascular disease: a long and winding road. J Am Coll Cardiol 43: 1738-1742 [Abstract] [Full text]  
  • Fagerlin, A., Rovner, D., Stableford, S., Jentoft, C., Wei, J. T., Holmes-Rovner, M. (2004). Patient Education Materials about the Treatment of Early-Stage Prostate Cancer: A Critical Review. ANN INTERN MED 140: 721-728 [Abstract] [Full text]  
  • Leighl, N. B., Butow, P. N., Tattersall, M. H.N. (2004). Treatment Decision Aids in Advanced Cancer: When the Goal Is Not Cure and the Answer Is Not Clear. JCO 22: 1759-1762 [Full text]  
  • Dent, J, Armstrong, D, Delaney, B, Moayyedi, P, Talley, N J, Vakil, N (2004). Symptom evaluation in reflux disease: workshop background, processes, terminology, recommendations, and discussion outputs. Gut 53: iv1-iv24 [Abstract] [Full text]  
  • Ruland, C. M, White, T., Stevens, M., Fanciullo, G., Khilani, S. M (2003). Effects of a Computerized System to Support Shared Decision Making in Symptom Management of Cancer Patients: Preliminary Results. J Am Med Inform Assoc 10: 573-579 [Abstract] [Full text]  
  • Ruland, C. M., White, T., Stevens, M., Fanciullo, G., Khilani, S. M. (2003). Effects of a Computerized System to Support Shared Decision Making in Symptom Management of Cancer Patients: Preliminary Results. J. Am. Med. Inform. Assoc. 10: 573-579 [Abstract] [Full text]  
  • Elwyn, G., Edwards, A., Britten, N. (2003). "Doing prescribing": how doctors can be more effective. BMJ 327: 864-867 [Full text]  
  • Edwards, A., Unigwe, S., Elwyn, G., Hood, K. (2003). Effects of communicating individual risks in screening programmes: Cochrane systematic review. BMJ 327: 703-709 [Abstract] [Full text]  
  • Adab, P, Marshall, T, Rouse, A, Randhawa, B, Sangha, H, Bhangoo, N (2003). Randomised controlled trial of the effect of evidence based information on women's willingness to participate in cervical cancer screening. J. Epidemiol. Community Health 57: 589-593 [Abstract] [Full text]  
  • Kravitz, R. L., Bell, R. A., Azari, R., Kelly-Reif, S., Krupat, E., Thom, D. H. (2003). Direct Observation of Requests for Clinical Services in Office Practice: What Do Patients Want and Do They Get It?. Arch Intern Med 163: 1673-1681 [Abstract] [Full text]  
  • Brehaut, J. C., O'Connor, A. M., Wood, T. J., Hack, T. F., Siminoff, L., Gordon, E., Feldman-Stewart, D. (2003). Validation of a Decision Regret Scale. Med Decis Making 23: 281-292 [Abstract]  
  • Jadad, A. R, Rizo, C. A, Enkin, M. W (2003). I am a good patient, believe it or not. BMJ 326: 1293-1295 [Full text]  
  • Whelan, T., Sawka, C., Levine, M., Gafni, A., Reyno, L., Willan, A., Julian, J., Dent, S., Abu-Zahra, H., Chouinard, E., Tozer, R., Pritchard, K., Bodendorfer, I. (2003). Helping Patients Make Informed Choices: A Randomized Trial of a Decision Aid for Adjuvant Chemotherapy in Lymph Node-Negative Breast Cancer. JNCI J Natl Cancer Inst 95: 581-587 [Abstract] [Full text]  
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  • Kennedy, A. D. M., Sculpher, M. J., Coulter, A., Dwyer, N., Rees, M., Abrams, K. R., Horsley, S., Cowley, D., Kidson, C., Kirwin, C., Naish, C., Stirrat, G. (2002). Effects of Decision Aids for Menorrhagia on Treatment Choices, Health Outcomes, and Costs: A Randomized Controlled Trial. JAMA 288: 2701-2708 [Abstract] [Full text]  
  • Walter, F. M, Britten, N. (2002). Patients' understanding of risk: a qualitative study of decision-making about the menopause and hormone replacement therapy in general practice. Fam Pract 19: 579-586 [Abstract] [Full text]  
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  • Straus, S. E., Majumdar, S. R., McAlister, F. A. (2002). New Evidence for Stroke Prevention: Clinical Applications. JAMA 288: 1396-1398 [Abstract] [Full text]  
  • Mulley, A. G. Jr., Sepucha, K. (2002). Making Good Decisions about Breast Cancer Chemoprevention. ANN INTERN MED 137: 52-54 [Full text]  
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  • Coulter, A. (2002). After Bristol: putting patients at the centre. Qual Saf Health Care 11: 186-188 [Abstract] [Full text]  
  • Straus, S. E (2002). Individualizing Treatment Decisions: The Likelihood of Being Helped or Harmed. Eval Health Prof 25: 210-224 [Abstract]  
  • Hudak, P. L., Clark, J. P., Hawker, G. A., Coyte, P. C., Mahomed, N. N., Kreder, H. J., Wright, J. G. (2002). "You're Perfect for the Procedure! Why Don't You Want It?" Elderly Arthritis Patients' Unwillingness to Consider Total Joint Arthroplasty Surgery: A Qualitative Study. Med Decis Making 22: 272-278 [Abstract]  
  • Sepucha, K. R., Belkora, J. K., Mutchnick, S., Esserman, L. J. (2002). Consultation Planning to Help Breast Cancer Patients Prepare for Medical Consultations: Effect on Communication and Satisfaction for Patients and Physicians. JCO 20: 2695-2700 [Abstract] [Full text]  
  • Dolan, J. G., Frisina, S. (2002). Randomized Controlled Trial of a Patient Decision Aid for Colorectal Cancer Screening. Med Decis Making 22: 125-139 [Abstract]  
  • Guyatt, G. H., Osoba, D., Wu, A. W., Wyrwich, K. W., Norman, G. R., Clinical Significance Consensus Meeting Group, (2002). Methods to Explain the Clinical Significance of Health Status Measures. Mayo Clin Proc. 77: 371-383 [Abstract]  
  • O'Cathain, A, Walters, S J, Nicholl, J P, Thomas, K J, Kirkham, M (2002). Use of evidence based leaflets to promote informed choice in maternity care: randomised controlled trial in everyday practice. BMJ 324: 643-643 [Abstract] [Full text]  
  • Coulter, A., Dunn, N. (2002). After Bristol: putting patients at the centre * Commentary: Patient centred care: timely, but is it practical?. BMJ 324: 648-651 [Full text]  
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  • Thomson, R., Clarke, A. (2002). Commentary. Qual Saf Health Care 11: 38-39 [Full text]  
  • Vincent, C A, Coulter, A (2002). Patient safety: what about the patient?. Qual Saf Health Care 11: 76-80 [Abstract] [Full text]  
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  • Lip, G. Y.H., Kamath, S., Jafri, M., Mohammed, A., Bareford, D., McAlister, F. A. (2002). Ethnic Differences in Patient Perceptions of Atrial Fibrillation and Anticoagulation Therapy: The West Birmingham Atrial Fibrillation Project * Editorial Comment: The West Birmingham Atrial Fibrillation Project. Stroke 33: 238-242 [Abstract] [Full text]  
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  • Donovan, J. L, Frankel, S. J, Neal, D. E, Hamdy, F. C (2001). Screening for prostate cancer in the UK. BMJ 323: 763-764 [Full text]  
  • Kravitz, R. L, Melnikow, J. (2001). Engaging patients in medical decision making. BMJ 323: 584-585 [Full text]  
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  • Sowden, A J, Forbes, C, Entwistle, V, Watt, I (2001). Informing, communicating and sharing decisions with people who have cancer. Qual Saf Health Care 10: 193-196 [Full text]  
  • Deyo, R. A (2001). A key medical decision maker: the patient. BMJ 323: 466-467 [Full text]  
  • Murray, E., Davis, H., Tai, S. S., Coulter, A., Gray, A., Haines, A. (2001). Randomised controlled trial of an interactive multimedia decision aid on hormone replacement therapy in primary care. BMJ 323: 490-490 [Abstract] [Full text]  
  • Bowling, A, Ebrahim, S (2001). Measuring patients' preferences for treatment and perceptions of risk. Qual Saf Health Care 10: i2-8 [Full text]  
  • Edwards, A, Elwyn, G (2001). Understanding risk and lessons for clinical risk communication about treatment preferences. Qual Saf Health Care 10: i9-13 [Abstract] [Full text]  
  • Bastian, L. A., Lipkus, I. M., Kuchibhatla, M. N., Weng, H. H., Halabi, S., Ryan, P. D., Skinner, C. S., Rimer, B. K. (2001). Women's Interest in Chemoprevention for Breast Cancer. Arch Intern Med 161: 1639-1644 [Abstract] [Full text]  
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  • Radwin, L. E (2001). A video programme plus a booklet was more effective than a booklet alone for increasing patient knowledge about lumbar spine treatment options for low back pain. Evid. Based Nurs. 4: 84-84 [Full text]  
  • Montgomery, A. A, Harding, J., Fahey, T. (2001). Shared decision making in hypertension: the impact of patient preferences on treatment choice. Fam Pract 18: 309-313 [Abstract] [Full text]  
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  • DAVIES, T. (2001). Informed consent in psychiatric research. Br. J. Psychiatry 178: 397-398 [Full text]  
  • Jones, R. B, Atkinson, J. M, Coia, D. A, Paterson, L., Morton, A R., McKenna, K., Craig, N., Morrison, J., Gilmour, W H. (2001). Randomised trial of personalised computer based information for patients with schizophrenia. BMJ 322: 835-840 [Abstract] [Full text]  
  • Holmes-Rovner, M., Llewellyn-Thomas, H., Entwistle, V., Coulter, A., O'Connor, A., Rovner, D. R (2001). Patient choice modules for summaries of clinical effectiveness: a proposal. BMJ 322: 664-667 [Full text]  
  • Molenaar, S., Sprangers, M. A., Rutgers, E. J. Th., Luiten, E. J., Mulder, J., Bossuyt, P. M., van Everdingen, J. J., Oosterveld, P., de Haes, H. C. (2001). Decision Support for Patients With Early-Stage Breast Cancer: Effects of an Interactive Breast Cancer CDROM on Treatment Decision, Satisfaction, and Quality of Life. JCO 19: 1676-1687 [Abstract] [Full text]  
  • Auerbach, S. M. (2001). Do Patients Want Control over their Own Health Care? A Review of Measures, Findings, and Research Issues. J Health Psychol 6: 191-203 [Abstract]  
  • Little, P., Everitt, H., Williamson, I., Warner, G., Moore, M., Gould, C., Ferrier, K., Payne, S. (2001). Preferences of patients for patient centred approach to consultation in primary care: observational study. BMJ 322: 468-468 [Abstract] [Full text]  
  • Straus, S. E, McAlister, F. (2001). Applying the results of trials and systematic reviews to our individual patients. Evid. Based Ment. Health 4: 6-7 [Full text]  
  • Clark, J. A., Wray, N. P., Ashton, C. M. (2001). Living With Treatment Decisions: Regrets and Quality of Life Among Men Treated for Metastatic Prostate Cancer. JCO 19: 72-80 [Abstract] [Full text]  
  • Robinson, A, Thomson, R G (2000). The potential use of decision analysis to support shared decision making in the face of uncertainty: the example of atrial fibrillation and warfarin anticoagulation. Qual Saf Health Care 9: 238-244 [Abstract] [Full text]  
  • Thornett, A., Cantekin, E. I, King, E., Lilford, R J, Braunholtz, D., Sandhu, G, Saleh, H A, Wright, T, Damoiseaux, R A M J, van Balen, F A M, Hoes, A W, Verheij, T J M, de Melker, R A (2000). Amoxicillin for otitis media in general practice. BMJ 321: 765-765 [Full text]  
  • Guyatt, G. H., Haynes, R. B., Jaeschke, R. Z., Cook, D. J., Green, L., Naylor, C. D., Wilson, M. C., Richardson, W. S., for the Evidence-Based Medicine Working Group, (2000). Users' Guides to the Medical Literature: XXV. Evidence-Based Medicine: Principles for Applying the Users' Guides to Patient Care. JAMA 284: 1290-1296 [Abstract] [Full text]  
  • Detmer, D. E (2000). Information technology for quality health care: a summary of United Kingdom and United States experiences. Qual Saf Health Care 9: 181-189 [Full text]  
  • McAlister, F. A., O'Connor, A. M., Wells, G., Grover, S. A., Laupacis, A. (2000). When should hypertension be treated? The different perspectives of Canadian family physicians and patients. CMAJ 163: 403-408 [Abstract] [Full text]  
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