Drug counselling improves adherence to antidepressants

Primary care patients given counselling on antidepressant drug treatment are more likely to adhere to treatment than are other patients. Non-adherence is a serious problem in depression, and Peveler et al (p 612) conducted a randomised trial comparing nurse counselling, leaflets, and no intervention on adherence to tricyclic antidepressants in general practice. Leaflets had no effect on adherence. Although adherence was improved by counselling, clinical benefit was apparent only in patients who met criteria for a major depressive episode and were taking doses of at least 75 mg.

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Relevant Article

Effect of antidepressant drug counselling and information leaflets on adherence to drug treatment in primary care: randomised controlled trial

Robert Peveler, Charles George, Ann-Louise Kinmonth, Michael Campbell, and Chris Thompson
BMJ 1999 319: 612-615. [Abstract] [Full Text] [PDF]