Double blind placebo controlled randomised trials of neuroleptics for behavioural and psychological signs in dementia

Study and year	Active agent	Duration (weeks)	Sample size	Mean age (years)	Mean outcome assessment	% Significantly improved	Comments
1960⁽¹⁾	Chlorpromazine	8	32	75	Clinical observation	NS	Proportions not specified
1962⁽²⁾	Trifluoperazine	8	27	71	Behavioural assessment scale	22 v 0	All medically unwell
1962⁽³⁾	Acetophonazine	8	19	71	Clinical observation	64 v 20
1964⁽⁴⁾	Haloperidol	6	18	71	Unvalidated checklist	89 v 67
1973⁽⁵⁾	Penfluridol		36	81	Beoordingsschaal Oudere Pattienten	NS	Portions not specified
1976⁽⁶⁾	Thiothixene		42	76	Brief psychiatric rating scale	59 v 55
1982⁽⁷⁾	Haloperidol loxepine	8	61	73	Brief psychiatric rating scale	65 v 58 v 36
1982⁽⁸⁾	Thioridozine loxepine	8	53	83	Brief psychiatric rating scale	59 v 68 v 47
1995⁽⁹⁾	Thiothixene	11	33	85	Cohen-Mansfield agitation inventory	65 v 19
1998⁽¹⁰⁾	Risperidone haloperidol	12	344	81	Behav-AD	76 v 69 v 61
1999⁽¹¹⁾	Risperidone	12	435	83	Behav-AD	68 v 61	Overall difference significant only for 2 mg/day

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