Zygosity influences glucose homeostasis and insulin resistance in twins
During fetal development monozygotic twins often share a placenta
(monochorionic), which may have an influence on glucose homeostasis in
later life. Poulsen et al (p 151) found that monozygotic twins were
more hyperglycaemic and hyperinsulinaemic (indicating insulin
resistance) than dizygotic twins during an oral glucose tolerance test,
supporting an intrauterine influence on glucose homeostasis and perhaps
on insulin resistance. To some extent the results may question the
validity of previous classic twin studies on the causes of type 2 diabetes.
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- Does zygosity influence the metabolic profile of twins? A population based cross sectional study
- Pernille Poulsen, Allan Vaag, and Henning Beck-Nielsen
BMJ 1999 319: 151-154.[Abstract] [Full Text] [PDF]
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