Leukotriene receptor antagonist reduces need for inhaled corticosteroids

The leukotriene receptor antagonist montelukast allows asthmatic patients to reduce their use of inhaled corticosteroids, a randomised placebo controlled trial has shown (p 87). Lofdahl et al found that patients given 10 mg daily montelukast could cut their use of inhaled corticosteroids by 47% compared with 30% in the placebo group. However, the study did not examine the effect of montelukast beyond 12 weeks and little is known about the long term effects of the drug.

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Relevant Article

Randomised, placebo controlled trial of effect of a leukotriene receptor antagonist, montelukast, on tapering inhaled corticosteroids in asthmatic patients

Claes-Göran Löfdahl, Theodore F Reiss, Jonathan A Leff, Elliot Israel, Michael J Noonan, Albert F Finn, Beth C Seidenberg, Thomas Capizzi, Sudeep Kundu, and Philippe Godard
BMJ 1999 319: 87-90. [Abstract] [Full Text] [PDF]