Terbinafine is best treatment for fungal nail infection

Fungal nail infection (onychomycosis) is common and can impair quality of life, but the condition is curable after a correct diagnosis. Until recently, griseofulvin was the only systemic treatment, but more effective and safer agents are now available. On p 1031 Evans and Sigurgeirsson report the results of a comparison of the efficacy and safety of continuous terbinafine with intermittent itraconazole in patients with dermatophyte toenail infection. They found terbinafine to be significantly more effective than itraconazole and well tolerated over 12 or 16 weeks of treatment. The data suggest that terbinafine should be the current treatment of choice for onychomycosis.

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Relevant Article

Double blind, randomised study of continuous terbinafine compared with intermittent itraconazole in treatment of toenail onychomycosis

E Glyn V Evans and Bárdur Sigurgeirsson
BMJ 1999 318: 1031-1035. [Abstract] [Full Text] [PDF]