Aspirin use does not contribute to intracerebral haemorrhage

The results of several large trials have shown a small excess of intracerebral haemorrhage among patients treated with aspirin. It is not clear, however, whether individuals taking low dose aspirin for the prophylaxis of vascular disease are at increased risk of intracerebral haemorrhage. Thrift et al (p 759) therefore studied 331 hospital patients and coroner's cases with intracerebral haemorrhage and age and sex matched controls based in the community. They found no increase in risk of intracerebral haemorrhage among aspirin users overall or among those using low doses of the drug. Users of high doses had a threefold increase in risk, but this finding requires confirmation.


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Relevant Article

Risk of primary intracerebral haemorrhage associated with aspirin and non-steroidal anti-inflammatory drugs: case-control study

Amanda G Thrift, John J McNeil, Andrew Forbes, and Geoffrey A Donnan
BMJ 1999 318: 759-764. [Abstract] [Full Text] [PDF]