Editorials

Delivering inhaled corticosteroids to patients

If side effects are important, why are we so ignorant of the dose inhaled? 

Inhaled steroids play an extremely important part in the treatment of asthma. They are now regarded as the first line prophylactic drug for adults¹ and are used by many as a first line prophylactic agent for children. Important side effects are rarely seen in users of low dose inhaled steroids, but there is concern over the potential effects of high dose inhaled steroids. The Committee on Safety of Medicines has recently concluded that clinically important systemic adverse effects can occur at licensed doses of inhaled corticosteroids,² the risks being increased after prolonged high dose therapy. Effects mentioned included adrenal suppression, osteoporosis or changes in bone mineral density, growth retardation in children, cataracts, and glaucoma. A major problem in trying to identify possible side effectsand, indeed, in assessing clinical trials of inhaled steroidsis determining the amount of drug patients have actually inhaled. Compliance and inhaler technique vary considerably, but even when these are optimal the dose of drug inhaled may vary by up to fourfold without the patient, prescriber, researcher, or regulator being aware.

Studies on the effect of inhaled steroids usually quote the prescribed dose. This is simply the strength of inhaler times the number of doses a patient is taking. For example, two actuations of a 100 µg strength (the nominal dose per actuation) metered dose inhaler twice daily is 400 µg/day. Marketing inhalers of different strengths and not making clear which is which on the label is forbidden by the Medicines Control Agency. However, when nebuliser and spacer devices are used the prescribed dose may bear little resemblance to the dose actually available for the patient to inhalethe received dose.

In the United Kingdom drug delivery devices made outside pharmaceutical companies may be marketed without a licence and sold to the general public. The manufacturers of such devices do not have to provide information on the amount of drug the patient is likely to receive when using their device, and pharmaceutical companies are required to provide information on drug delivery devices only if they recommend a specific device for their product.

The type of device used may affect the delivery of inhaled steroids. For instance, beclomethasone dipropionate administered by nebulisation actually delivered a fraction of a similar nominal dose delivered by large volume spacer.³ Major differences in the dose inhaled may also occur between devices of the same class. We have recently found that the dose of budesonide a 10 year old patient may inhale from a "breath enhanced, open vent" nebuliser is four times that available from an "open vent" device and twice that available from a conventional nebuliser (unpublished). Parents buying a nebuliser will be totally unaware that the dose of steroid their child will inhale may vary by a factor of four depending on their choice of nebuliser.

The effect of the drug delivery device used on the level of side effects is rarely taken into account when evaluating side effects. In many published studies it is not clear how patients took their medication. For example, a recent study identified a possible association between the use of inhaled steroids and the development of posterior subcapsular and nuclear cataracts.⁴ Higher cumulative lifetime doses of beclomethasone dipropionate were associated with higher risks of posterior subcapsular cataracts, the highest prevalence (27%) being found in subjects whose lifetime dose was over 2000 mg. It would be of interest, and reassuring, to know whether patients using a spacer device had a lower incidence of side effects. Spacer devices used with pressurised metered dose inhalers reduce oropharyngeal deposition of aerosolised steroids,⁵ and hence the total body dose, without affecting the dose delivered to the airways. Their use has been documented to reduce hypothalamic-pituitary axis suppression by beclomethasone dipropionate,⁶ and the British asthma guidelines recommend their use for the delivery of inhaled steroids.

Without information on the likely dose of drug inhaled, the results of clinical trials may also be misinterpreted.⁷ If more than one type of nebuliser or spacer is used in a trial the results should not be pooled as patients will probably have received different doses. The practice of subjecting patients to the risks and inconvenience of a clinical trial without taking the confounding effect of different drug delivery devices into account should be questioned. Similarly, regulatory authorities should review the information required of the manufacturers of drugs and drug delivery devices about the delivery of inhaled steroids. This may help in interpreting trial data for therapeutic effect and possible side effects. Advisory bodies on asthma management may also be able to give more informed information to both prescribers and patients.

Although significant side effects are apparently rare in users of low dose inhaled steroids, information on the dose of drug inhaled is of therapeutic importance. Patients are being prescribed inhaled steroids at younger ages, and lifetime doses may greatly exceed those reported in the current literature. Current advice remains that the dose of inhaled steroid, whatever the delivery device, should be titrated to the lowest dose at which effective control of asthma is maintained.

Christopher O'Callaghan, Senior lecturer in child health. 
Peter Barry, Lecturer in child health. 

Department of Child Health, Leicester Royal Infirmary, Leicester LE2 7LX

1. British Thoracic Society. The British guidelines on asthma management: 1995 review and position statement. Thorax 1997; 52 (suppl 1): S1-24[Medline].
2. Committee on Safety of Medicines. Focus on corticosteroids. Current Problems in Pharmacovigilance 1998; 24: 5-10.
3. O'Callaghan C. Particle size of beclomethasone dipropionate produced by two nebulisers and two spacing devices. Thorax 1990; 45: 109-111[Abstract].
4. Cumming RG, Mitchell P, Leeder SR. Use of inhaled corticosteroids and the risk of cataract. N Engl J Med 1997; 337: 8-14[Abstract/Free Full Text].
5. Selroos O, Halme M. The effect of a Volumatic spacer and mouth rinsing on systemic absorption of inhaled corticosteroids from a metered dose inhaler and dry powder inhaler. Thorax 1991; 46: 891-894[Abstract].
6. Brown P, Blundell G, Greening A, Crompton G. Do large volume spacer devices reduce systemic effects of high dose inhaled corticosteroids? Thorax 1990; 45: 736-739[Abstract].
7. O'Callaghan C, Barry PW. Spacer devices in the treatment of asthma. BMJ 1997; 314: 1061-1062[Free Full Text].